C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: regulatory factor X, 3 (influences HLA class II expression)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040929 Rfx3 10090 - 19:27761721-28011166 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000046898 Rfx3-003 27766441-28011048 protein_coding
  ENSMUST00000165566 Rfx3-201 27761721-27982948 protein_coding
  ENSMUST00000172498 Rfx3-006 27768141-27836846 processed_transcript
  ENSMUST00000172907 Rfx3-004 27768318-28011045 protein_coding
  ENSMUST00000173161 Rfx3-002 27805143-28011166 retained_intron
  ENSMUST00000173863 Rfx3-005 27768455-27900895 nonsense_mediated_decay
  ENSMUST00000174420 Rfx3-007 27867515-28010790 protein_coding
  ENSMUST00000174850 Rfx3-001 27768139-28011140 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000046898ENSMUST00000165566ENSMUST00000172498ENSMUST00000172907ENSMUST00000173863ENSMUST00000174850
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000046898 N/A N/A N/A 0.524±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000165566 0.069±0.00 0.478±0.14 3.139±0.66 0.655±0.09 0.404±0.13 N/A 0.776±0.10 0.131±0.01 N/A 0.098±0.05 1.471±0.67 0.288±0.16 0.567±0.40
ENSMUST00000172498 N/A N/A N/A N/A N/A 0.192±0.00 N/A N/A N/A N/A 1.228±0.00 N/A N/A
ENSMUST00000172907 0.449±0.25 N/A N/A 0.357±0.00 0.531±0.22 0.251±0.05 0.452±0.09 0.132±0.00 0.471±0.00 N/A 1.317±0.26 0.565±0.00 8.182±2.26
ENSMUST00000173863 N/A N/A N/A N/A 0.421±0.00 N/A N/A 0.276±0.00 N/A N/A 2.552±0.39 N/A 4.790±0.73
ENSMUST00000174850 0.504±0.00 0.304±0.00 4.696±0.00 N/A 0.154±0.00 0.152±0.00 N/A N/A N/A N/A 1.175±0.19 N/A 5.909±0.45

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000NH CIL_0000NH_0002 CGP 19:27388702-28011166
CIL_0009AI CIL_0009AI_0002 VISTA 19:27604248-28205597
CIL_0000F0 CIL_0000F0_0002 CGP 19:27761721-28680077

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0003677 IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005667 IC transcription factor complex
GO:0006351 IMP transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007368 IMP determination of left/right symmetry
GO:0031018 IMP endocrine pancreas development
GO:0042384 IMP cilium assembly
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048469 IMP cell maturation
GO:0050796 IMP regulation of insulin secretion
GO:0060285 IMP cilium-dependent cell motility
GO:0060287 IMP epithelial cilium movement involved in determination of left/right asymmetry
GO:0072560 IMP type B pancreatic cell maturation
GO:2000078 IMP positive regulation of type B pancreatic cell development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014550 rfx3 regulatory factor X, 3 (influences HLA class II expression) protein_coding Danio_rerio
ENSG00000080298 RFX3 regulatory factor X, 3 (influences HLA class II expression) protein_coding Homo_sapiens

Loading