C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histocompatibility 2, class II antigen A, beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000073421 H2-Ab1 10090 + 17:34263209-34269418 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000040828 H2-Ab1-001 34263209-34269418 protein_coding
  ENSMUST00000173103 H2-Ab1-003 34267102-34268034 retained_intron
  ENSMUST00000174875 H2-Ab1-002 34268270-34269394 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000040828ENSMUST00000173103ENSMUST00000174875
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000040828 373.476±71.29 183.337±36.10 112.444±10.45 0.486±0.14 993.054±243.86 272.781±30.79 57.580±22.40 164.666±22.41 24.777±22.17 504.754±132.77 14.563±14.74 287.639±119.84 5.713±9.57 11.183±5.40
ENSMUST00000173103 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.230±0.00
ENSMUST00000174875 N/A N/A N/A N/A 1005.050±0.00 N/A N/A N/A N/A N/A N/A 23.821±7.92 0.250±0.04 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PK CIL_0001PK_0006 CGP 17:34238903-34269418
CIL_0002XS CIL_0002XS_0009 CGP 17:34263209-34287827

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002344 IDA B cell affinity maturation
GO:0002579 IDA positive regulation of antigen processing and presentation
GO:0002827 IDA positive regulation of T-helper 1 type immune response
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005769 IDA early endosome
GO:0005771 IDA multivesicular body
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0006955 IMP immune response
GO:0008134 IDA transcription factor binding
GO:0009897 IDA external side of plasma membrane
GO:0015643 IPI toxic substance binding
GO:0016021 IDA integral component of membrane
GO:0019882 IDA antigen processing and presentation
GO:0019886 IDA antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031625 IPI ubiquitin protein ligase binding
GO:0042605 IDA peptide antigen binding
GO:0042613 IDA MHC class II protein complex
GO:0046635 IDA positive regulation of alpha-beta T cell activation
GO:0048002 IDA antigen processing and presentation of peptide antigen
GO:0070491 IPI repressing transcription factor binding
GO:0071346 IDA cellular response to interferon-gamma

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041705 si:busm1-228j01.6 si:busm1-228j01.6 protein_coding Danio_rerio
ENSDARG00000053738 si:dkey-33b17.3 si:dkey-33b17.3 protein_coding Danio_rerio
ENSDARG00000054921 wu:fd58b11 wu:fd58b11 protein_coding Danio_rerio
ENSDARG00000055447 si:busm1-194e12.12 si:busm1-194e12.12 protein_coding Danio_rerio
ENSDARG00000056330 mhc2dbb major histocompatibility complex class II DBB gene protein_coding Danio_rerio
ENSDARG00000074510 si:busm1-104n07.3 si:busm1-104n07.3 protein_coding Danio_rerio
ENSDARG00000076307 si:zfos-2070c2.3 si:zfos-2070c2.3 protein_coding Danio_rerio
ENSDARG00000079105 mhc2dab major histocompatibility complex class II DAB gene protein_coding Danio_rerio
ENSDARG00000088872 si:busm1-228j01.4 si:busm1-228j01.4 protein_coding Danio_rerio
ENSDARG00000093706 si:dkey-33b17.3 si:dkey-33b17.3 protein_coding Danio_rerio
ENSG00000179344 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 protein_coding Homo_sapiens
ENSG00000232629 HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 protein_coding Homo_sapiens

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