C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: caveolin 1, caveolae protein
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000007799 Cav1-001 ENSMUSG00000007655 10090 + 6:17306335-17341324 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000007799
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000007799 301.548±159.67 11.848±2.54 226.661±15.00 3.199±1.54 116.023±18.29 18.498±2.10 46.524±3.52 9.264±1.38 1.148±0.93 201.534±21.52 34.579±4.69 29.503±18.87 18.367±17.13 1.907±1.09

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SP CIL_0007SP_0002 VISTA 6:16868699-17474875
CIL_00063M CIL_00063M_0003 CGP 6:17281185-17341452
CIL_00063L CIL_00063L_0003 CGP 6:17306335-17573980

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000139 IEA:ISS Golgi membrane
GO:0000165 IMP MAPK cascade
GO:0000188 IMP inactivation of MAPK activity
GO:0001525 IGI angiogenesis
GO:0001570 IMP vasculogenesis
GO:0001666 IMP response to hypoxia
GO:0001937 IMP negative regulation of endothelial cell proliferation
GO:0001960 IMP negative regulation of cytokine-mediated signaling pathway
GO:0002026 IMP regulation of the force of heart contraction
GO:0002080 IDA acrosomal membrane
GO:0002931 IMP response to ischemia
GO:0003057 IGI regulation of the force of heart contraction by chemical signal
GO:0005102 IEA receptor binding
GO:0005198 IEA structural molecule activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005768 ISS endosome
GO:0005783 IDA:ISS endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005901 TAS:ISS caveola
GO:0005925 IEA focal adhesion
GO:0005929 IDA cilium
GO:0005938 IDA cell cortex
GO:0006641 IMP triglyceride metabolic process
GO:0006816 IMP calcium ion transport
GO:0006874 IMP cellular calcium ion homeostasis
GO:0006897 TAS endocytosis
GO:0006940 IMP regulation of smooth muscle contraction
GO:0007519 IMP skeletal muscle tissue development
GO:0007595 IMP lactation
GO:0008104 IMP protein localization
GO:0008285 IMP negative regulation of cell proliferation
GO:0009267 IEA cellular response to starvation
GO:0009968 IDA negative regulation of signal transduction
GO:0010524 IDA positive regulation of calcium ion transport into cytosol
GO:0010952 IMP positive regulation of peptidase activity
GO:0016020 IDA membrane
GO:0016021 IDA integral component of membrane
GO:0016050 IEA vesicle organization
GO:0016323 IEA basolateral plasma membrane
GO:0016324 IEA apical plasma membrane
GO:0016504 IMP peptidase activator activity
GO:0019217 IMP regulation of fatty acid metabolic process
GO:0019899 IEA enzyme binding
GO:0019915 IMP lipid storage
GO:0030193 IEA regulation of blood coagulation
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0030857 IMP negative regulation of epithelial cell differentiation
GO:0030879 IMP mammary gland development
GO:0031295 ISS T cell costimulation
GO:0031397 IMP negative regulation of protein ubiquitination
GO:0031410 ISO cytoplasmic vesicle
GO:0032091 IEA negative regulation of protein binding
GO:0032570 ISO response to progesterone
GO:0033137 IEA negative regulation of peptidyl-serine phosphorylation
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0033484 IMP nitric oxide homeostasis
GO:0042310 IMP vasoconstriction
GO:0042524 IDA negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042632 IMP cholesterol homeostasis
GO:0043234 IPI protein complex
GO:0043407 IMP negative regulation of MAP kinase activity
GO:0043409 IMP negative regulation of MAPK cascade
GO:0043627 IDA response to estrogen
GO:0045019 IMP negative regulation of nitric oxide biosynthetic process
GO:0045121 IDA membrane raft
GO:0045907 IMP positive regulation of vasoconstriction
GO:0046426 IDA negative regulation of JAK-STAT cascade
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048550 IEA negative regulation of pinocytosis
GO:0048554 IMP positive regulation of metalloenzyme activity
GO:0050998 IEA nitric-oxide synthase binding
GO:0051001 IMP negative regulation of nitric-oxide synthase activity
GO:0051259 IDA protein oligomerization
GO:0051260 IDA protein homooligomerization
GO:0051480 IEA cytosolic calcium ion homeostasis
GO:0051592 IDA response to calcium ion
GO:0051899 IMP membrane depolarization
GO:0052547 IMP regulation of peptidase activity
GO:0055074 IMP calcium ion homeostasis
GO:0060056 IMP mammary gland involution
GO:0070836 IMP caveola assembly
GO:0071455 IEA cellular response to hyperoxia
GO:0072584 IEA caveolin-mediated endocytosis
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway
GO:0097190 IEA apoptotic signaling pathway
GO:2000286 IEA receptor internalization involved in canonical Wnt signaling pathway
GO:2000811 IMP negative regulation of anoikis
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway
GO:2001244 IEA positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000061076 cav1-201 protein_coding Danio_rerio 0 254
ENSDART00000148700 cav1-002 protein_coding Danio_rerio 0 254
ENSDART00000149865 cav1-001 protein_coding Danio_rerio 0 254
ENST00000341049 CAV1-001 protein_coding Homo_sapiens 0 937
ENST00000393467 CAV1-003 protein_coding Homo_sapiens 0 760
ENST00000393468 CAV1-004 protein_coding Homo_sapiens 0 752
ENST00000393470 CAV1-006 protein_coding Homo_sapiens 0 676
ENST00000405348 CAV1-008 protein_coding Homo_sapiens 0 758
ENST00000451122 CAV1-002 nonsense_mediated_decay Homo_sapiens 0 760
ENST00000456473 CAV1-007 protein_coding Homo_sapiens 0 693
ENST00000489856 CAV1-005 retained_intron Homo_sapiens 0 357
ENST00000614113 CAV1-201 protein_coding Homo_sapiens 0 760

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