C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: DNA methyltransferase 3A
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000020991 Dnmt3a-001 ENSMUSG00000020661 10090 + 12:3807030-3914443 protein_coding

Mus musculus EnsemblGRCm38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020991
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020991 5.848±2.23 4.136±1.61 3.455±0.03 8.970±2.98 4.730±2.39 4.895±1.01 3.561±1.18 3.465±1.72 1.275±0.52 5.046±1.74 4.216±0.88 11.052±1.78 5.399±0.65 0.816±0.27

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000775 IDA chromosome, centromeric region
GO:0000791 ISS euchromatin
GO:0000792 IDA heterochromatin
GO:0001741 IDA XY body
GO:0003677 IDA:ISS DNA binding
GO:0003682 IDA chromatin binding
GO:0003886 IDA:ISS DNA (cytosine-5-)-methyltransferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA:ISS nucleus
GO:0005720 IDA nuclear heterochromatin
GO:0005737 IDA:ISS cytoplasm
GO:0006306 IDA:ISS DNA methylation
GO:0006346 IDA methylation-dependent chromatin silencing
GO:0006349 IMP regulation of gene expression by genetic imprinting
GO:0006351 IEA transcription, DNA-templated
GO:0007283 IMP spermatogenesis
GO:0008168 TAS methyltransferase activity
GO:0010216 TAS maintenance of DNA methylation
GO:0010424 IEA DNA methylation on cytosine within a CG sequence
GO:0016363 ISS nuclear matrix
GO:0042802 IEA identical protein binding
GO:0043045 IMP DNA methylation involved in embryo development
GO:0043046 IMP DNA methylation involved in gamete generation
GO:0044027 IDA hypermethylation of CpG island
GO:0045322 IEA unmethylated CpG binding
GO:0046498 IEA S-adenosylhomocysteine metabolic process
GO:0046499 IEA S-adenosylmethioninamine metabolic process
GO:0046872 IEA metal ion binding
GO:0051718 IEA DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0071230 IDA cellular response to amino acid stimulus
GO:0090116 IDA:IEA C-5 methylation of cytosine

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000127557 dnmt3ab-202 protein_coding Danio_rerio 0 1046
ENSDART00000005239 dnmt3ab-201 protein_coding Danio_rerio 0 1046
ENSDART00000126823 dnmt3ab-001 protein_coding Danio_rerio 0 1046
ENSDART00000151921 dnmt3ab-002 protein_coding Danio_rerio 0 1046
ENST00000264709 DNMT3A-001 protein_coding Homo_sapiens 0 4115
ENST00000321117 DNMT3A-011 protein_coding Homo_sapiens 0 4135
ENST00000380746 DNMT3A-002 protein_coding Homo_sapiens 0 3315
ENST00000380756 DNMT3A-010 nonsense_mediated_decay Homo_sapiens 0 3090
ENST00000402667 DNMT3A-013 protein_coding Homo_sapiens 0 2970
ENST00000406659 DNMT3A-012 protein_coding Homo_sapiens 0 518
ENST00000455096 AC009474.1-001 processed_pseudogene Homo_sapiens 0 1018
ENST00000461228 DNMT3A-006 processed_transcript Homo_sapiens 0 688
ENST00000466601 DNMT3A-007 retained_intron Homo_sapiens 0 809
ENST00000470983 DNMT3A-003 processed_transcript Homo_sapiens 0 682
ENST00000474807 DNMT3A-004 retained_intron Homo_sapiens 0 900
ENST00000474887 DNMT3A-008 processed_transcript Homo_sapiens 0 1094
ENST00000482935 DNMT3A-015 processed_transcript Homo_sapiens 0 675
ENST00000484184 DNMT3A-005 retained_intron Homo_sapiens 0 265
ENST00000491288 DNMT3A-009 processed_transcript Homo_sapiens 0 486
ENST00000496570 DNMT3A-017 processed_transcript Homo_sapiens 0 658

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