C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: F-box and WD-40 domain protein 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000029727 Fbxw7-002 ENSMUSG00000028086 10090 + 3:84952146-84977645 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastOvaryENSMUST00000029727
Transcript ID Brain Breast Ovary
ENSMUST00000029727 18.411±16.00 1.485±0.00 3.268±0.82

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00064N CIL_00064N_0002 CGP 3:84444035-85887516
CIL_0004PH CIL_0004PH_0002 CGP 3:84496093-85887516
CIL_0008CH CIL_0008CH_0002 VISTA 3:84637097-85239573

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001570 IMP vasculogenesis
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005737 TAS cytoplasm
GO:0005739 IDA mitochondrion
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0007062 ISS sister chromatid cohesion
GO:0007219 IDA Notch signaling pathway
GO:0016021 NAS integral component of membrane
GO:0016567 ISS protein ubiquitination
GO:0019005 ISS SCF ubiquitin ligase complex
GO:0030324 IMP lung development
GO:0030332 ISS cyclin binding
GO:0030674 ISS protein binding, bridging
GO:0031146 ISS SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 ISS positive regulation of protein ubiquitination
GO:0031625 ISS ubiquitin protein ligase binding
GO:0032876 ISS negative regulation of DNA endoreduplication
GO:0034644 ISS cellular response to UV
GO:0042802 ISS identical protein binding
GO:0045741 ISS positive regulation of epidermal growth factor-activated receptor activity
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050821 ISS protein stabilization
GO:0051443 ISS positive regulation of ubiquitin-protein transferase activity
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0097027 ISS ubiquitin-protein transferase activator activity
GO:1901800 IMP positive regulation of proteasomal protein catabolic process
GO:1903378 IMP positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990452 ISS Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000060 ISS positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000086512 FBXW7-201 protein_coding Danio_rerio 0 1064
ENSDART00000148076 FBXW7-001 protein_coding Danio_rerio 0 1064
ENST00000263981 FBXW7-005 protein_coding Homo_sapiens 0 3112
ENST00000281708 FBXW7-001 protein_coding Homo_sapiens 0 2409
ENST00000296555 FBXW7-003 protein_coding Homo_sapiens 0 2403
ENST00000393956 FBXW7-007 protein_coding Homo_sapiens 0 2276
ENST00000603548 FBXW7-002 protein_coding Homo_sapiens 0 2409
ENST00000603821 FBXW7-008 retained_intron Homo_sapiens 0 553
ENST00000603841 FBXW7-012 protein_coding Homo_sapiens 0 2398
ENST00000604069 FBXW7-010 retained_intron Homo_sapiens 0 808
ENST00000604316 FBXW7-011 retained_intron Homo_sapiens 0 741
ENST00000604822 FBXW7-009 retained_intron Homo_sapiens 0 645

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