C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: RAR-related orphan receptor alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000034766 Rora-001 ENSMUSG00000032238 10090 + 9:68653786-69388246 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034766
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034766 2.727±0.29 7.506±1.80 0.909±0.00 2.260±1.43 2.374±0.61 1.221±0.21 1.324±0.51 2.534±1.01 3.074±1.57 4.127±0.45 0.991±0.09 2.320±0.42 1.146±0.73 0.759±0.21

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YJ CIL_0008YJ_0002 VISTA 9:68494558-69097064
CIL_0005GZ CIL_0005GZ_0002 CGP 9:68653786-69433122

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001222 IEA transcription corepressor binding
GO:0001223 IPI transcription coactivator binding
GO:0001525 ISS angiogenesis
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006805 IMP xenobiotic metabolic process
GO:0006809 IMP nitric oxide biosynthetic process
GO:0007623 IEA circadian rhythm
GO:0008013 IPI beta-catenin binding
GO:0008134 IEA transcription factor binding
GO:0008142 ISS oxysterol binding
GO:0008270 IEA zinc ion binding
GO:0008589 IMP regulation of smoothened signaling pathway
GO:0010575 ISS positive regulation vascular endothelial growth factor production
GO:0010906 IMP regulation of glucose metabolic process
GO:0019218 IMP regulation of steroid metabolic process
GO:0021702 IMP cerebellar Purkinje cell differentiation
GO:0021930 IMP cerebellar granule cell precursor proliferation
GO:0030522 ISS intracellular receptor signaling pathway
GO:0032922 IDA circadian regulation of gene expression
GO:0036315 ISS cellular response to sterol
GO:0042692 ISS muscle cell differentiation
GO:0042752 IMP regulation of circadian rhythm
GO:0042753 IDA positive regulation of circadian rhythm
GO:0043030 IMP regulation of macrophage activation
GO:0043124 ISS negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 ISS sequence-specific DNA binding
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046068 IMP cGMP metabolic process
GO:0050728 ISS negative regulation of inflammatory response
GO:0060850 IDA regulation of transcription involved in cell fate commitment
GO:0070328 IMP triglyceride homeostasis
GO:0071456 ISS cellular response to hypoxia
GO:0072539 IMP T-helper 17 cell differentiation
GO:0098531 ISS direct ligand regulated sequence-specific DNA binding transcription factor activity
GO:2000188 IMP regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000148537 roraa-001 protein_coding Danio_rerio 0 254
ENST00000261523 RORA-003 protein_coding Homo_sapiens 0 1925
ENST00000309157 RORA-002 protein_coding Homo_sapiens 0 1925
ENST00000335670 RORA-001 protein_coding Homo_sapiens 0 2185
ENST00000449337 RORA-005 protein_coding Homo_sapiens 0 1925
ENST00000551975 RORA-004 nonsense_mediated_decay Homo_sapiens 0 745
ENST00000557822 RORA-008 retained_intron Homo_sapiens 0 411
ENST00000558234 RORA-006 retained_intron Homo_sapiens 9e-34 150
ENST00000559145 RORA-010 processed_transcript Homo_sapiens 0 248
ENST00000559343 RORA-009 protein_coding Homo_sapiens 0 381
ENST00000559587 RORA-007 processed_transcript Homo_sapiens 0 512
ENST00000560004 RORA-012 processed_transcript Homo_sapiens 0 616
ENST00000560300 RORA-013 processed_transcript Homo_sapiens 0 211
ENST00000561093 RORA-011 retained_intron Homo_sapiens 0 250

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