C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cholinergic receptor, nicotinic, alpha polypeptide 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000034851 Chrna3-201 ENSMUSG00000032303 10090 - 9:55011343-55026559 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000034851
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000034851 0.014±0.00 11.111±3.77 0.167±0.02 3.372±2.40 0.026±0.01 2.758±0.27 0.282±0.08 0.576±0.32 0.010±0.01 0.068±0.03 0.051±0.04 0.020±0.02 0.048±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003TT CIL_0003TT_0002 CGP 9:54980880-55026559
CIL_0001KZ CIL_0001KZ_0002 CGP 9:55011343-55048544

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004889 IMP acetylcholine-activated cation-selective channel activity
GO:0005515 IPI protein binding
GO:0005892 IPI acetylcholine-gated channel complex
GO:0006812 IMP cation transport
GO:0006937 IMP regulation of muscle contraction
GO:0006940 IMP regulation of smooth muscle contraction
GO:0007165 IEA signal transduction
GO:0007171 IMP activation of transmembrane receptor protein tyrosine kinase activity
GO:0007271 IMP synaptic transmission, cholinergic
GO:0007399 IEA nervous system development
GO:0007626 IMP locomotory behavior
GO:0014056 IMP regulation of acetylcholine secretion, neurotransmission
GO:0015464 IEA acetylcholine receptor activity
GO:0030054 IEA cell junction
GO:0035095 IMP behavioral response to nicotine
GO:0042391 IMP regulation of membrane potential
GO:0045211 IC postsynaptic membrane
GO:0048814 IMP regulation of dendrite morphogenesis
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0060084 IMP synaptic transmission involved in micturition
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000031546 chrna6-001 protein_coding Danio_rerio 1e-26 126
ENST00000276410 CHRNA6-001 protein_coding Homo_sapiens 0 322
ENST00000326828 CHRNA3-001 protein_coding Homo_sapiens 0 1805
ENST00000348639 CHRNA3-002 protein_coding Homo_sapiens 0 1633
ENST00000530869 CHRNA6-003 processed_transcript Homo_sapiens 0.00000000003 73
ENST00000533810 CHRNA6-005 protein_coding Homo_sapiens 2e-33 147
ENST00000558903 CHRNA3-008 processed_transcript Homo_sapiens 0 627
ENST00000559002 CHRNA3-004 processed_transcript Homo_sapiens 9.99967e-42 172
ENST00000559080 CHRNA3-007 protein_coding Homo_sapiens 0 202
ENST00000559658 CHRNA3-003 nonsense_mediated_decay Homo_sapiens 0 1805
ENST00000561128 CHRNA3-005 retained_intron Homo_sapiens 0 248

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