C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cholinergic receptor, nicotinic, alpha 3 (neuronal)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000326828 CHRNA3-001 ENSG00000080644 9606 - 15:78595305-78621179 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonLiverPlacentaTestisENST00000326828
Transcript ID Adrenal Breast Colon Liver Placenta Testis
ENST00000326828 1.112±0.00 0.566±0.00 1.381±0.99 0.304±0.00 0.099±0.00 0.357±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003TW CIL_0003TW_0001 CGP 15:78540405-78595269
CIL_0003TT CIL_0003TT_0001 CGP 15:78565520-78621295
CIL_0001KZ CIL_0001KZ_0001 CGP 15:78593052-78727754

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004889 TAS acetylcholine-activated cation-selective channel activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005515 IEA protein binding
GO:0005886 TAS plasma membrane
GO:0005892 IDA acetylcholine-gated channel complex
GO:0006810 IEA transport
GO:0006811 NAS:IEA ion transport
GO:0006812 TAS cation transport
GO:0006937 IEA regulation of muscle contraction
GO:0006940 ISS regulation of smooth muscle contraction
GO:0007165 IDA signal transduction
GO:0007171 ISS activation of transmembrane receptor protein tyrosine kinase activity
GO:0007268 TAS synaptic transmission
GO:0007271 ISS synaptic transmission, cholinergic
GO:0007399 IMP nervous system development
GO:0007626 ISS locomotory behavior
GO:0014056 ISS regulation of acetylcholine secretion, neurotransmission
GO:0014069 ISS postsynaptic density
GO:0015276 TAS ligand-gated ion channel activity
GO:0015464 IDA acetylcholine receptor activity
GO:0016020 IEA membrane
GO:0016021 NAS:IEA integral component of membrane
GO:0030054 IEA cell junction
GO:0030425 ISS dendrite
GO:0034220 TAS ion transmembrane transport
GO:0035095 IMP behavioral response to nicotine
GO:0042166 IC acetylcholine binding
GO:0042391 ISS regulation of membrane potential
GO:0043025 ISS neuronal cell body
GO:0045211 IEA postsynaptic membrane
GO:0048814 ISS regulation of dendrite morphogenesis
GO:0060079 ISS regulation of excitatory postsynaptic membrane potential
GO:0060084 IMP synaptic transmission involved in micturition
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034851 Chrna3-201 protein_coding Mus_musculus 0 1805
ENSMUST00000033882 Chrna6-201 protein_coding Mus_musculus 0 470
ENSDART00000079613 chrna2b-201 protein_coding Danio_rerio 0 307
ENSDART00000136317 chrna2b-001 protein_coding Danio_rerio 0 307
ENSMUST00000029562 Chrnb2-201 protein_coding Mus_musculus 2e-35 156
ENSDART00000031546 chrna6-001 protein_coding Danio_rerio 1e-17 97

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