C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sine oculis-related homeobox 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000050029 Six1-001 ENSMUSG00000051367 10090 - 12:73041827-73047179 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000050029
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000050029 2.302±1.44 0.984±0.44 0.521±0.00 0.120±0.08 1.790±0.75 0.016±0.00 0.222±0.07 0.210±0.04 0.050±0.07 1.455±0.17 15.376±2.72 0.287±0.21 0.042±0.04 0.321±0.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MW CIL_0008MW_0002 VISTA 12:72750612-73352572
CIL_00036B CIL_00036B_0003 CGP 12:72939892-73053887
CIL_0006SM CIL_0006SM_0003 CGP 12:73040015-73113456

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001657 IMP ureteric bud development
GO:0001658 IGI branching involved in ureteric bud morphogenesis
GO:0001759 IMP organ induction
GO:0001822 IMP kidney development
GO:0003151 IGI outflow tract morphogenesis
GO:0003682 IGI chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005730 IEA nucleolus
GO:0005737 IEA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006915 IEA apoptotic process
GO:0007389 IGI pattern specification process
GO:0007519 IGI skeletal muscle tissue development
GO:0007605 IMP sensory perception of sound
GO:0008582 IGI regulation of synaptic growth at neuromuscular junction
GO:0010468 IGI regulation of gene expression
GO:0014842 IDA regulation of satellite cell proliferation
GO:0021610 IMP facial nerve morphogenesis
GO:0022008 IMP neurogenesis
GO:0030855 IMP epithelial cell differentiation
GO:0030878 IMP thyroid gland development
GO:0030910 IMP olfactory placode formation
GO:0032880 IGI regulation of protein localization
GO:0034504 IEA protein localization to nucleus
GO:0035909 IGI aorta morphogenesis
GO:0042472 IGI inner ear morphogenesis
GO:0042474 IMP middle ear morphogenesis
GO:0043066 IMP negative regulation of apoptotic process
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043586 IMP tongue development
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045664 IMP regulation of neuron differentiation
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048538 IGI thymus development
GO:0048665 IGI neuron fate specification
GO:0048699 IMP generation of neurons
GO:0048701 IGI embryonic cranial skeleton morphogenesis
GO:0048704 IGI embryonic skeletal system morphogenesis
GO:0048705 IMP skeletal system morphogenesis
GO:0048839 IMP inner ear development
GO:0048856 IGI anatomical structure development
GO:0050678 IMP regulation of epithelial cell proliferation
GO:0051451 IGI myoblast migration
GO:0060037 IMP pharyngeal system development
GO:0061055 IMP myotome development
GO:0061197 IMP fungiform papilla morphogenesis
GO:0061551 IMP trigeminal ganglion development
GO:0071599 IMP otic vesicle development
GO:0072001 IGI renal system development
GO:0072075 IMP metanephric mesenchyme development
GO:0072095 IMP regulation of branch elongation involved in ureteric bud branching
GO:0072107 IMP positive regulation of ureteric bud formation
GO:0072172 IMP mesonephric tubule formation
GO:0072193 IMP ureter smooth muscle cell differentiation
GO:0072513 IGI positive regulation of secondary heart field cardioblast proliferation
GO:0090103 IMP cochlea morphogenesis
GO:0090190 IMP positive regulation of branching involved in ureteric bud morphogenesis
GO:0090191 IMP negative regulation of branching involved in ureteric bud morphogenesis
GO:2000729 IGI positive regulation of mesenchymal cell proliferation involved in ureter development
GO:2001014 IDA regulation of skeletal muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000247182 SIX1-001 protein_coding Homo_sapiens 0 1622
ENST00000303077 SIX2-001 protein_coding Homo_sapiens 0 676
ENST00000553535 SIX1-002 processed_transcript Homo_sapiens 0 606
ENST00000554986 SIX1-005 protein_coding Homo_sapiens 0 728
ENST00000555955 SIX1-004 retained_intron Homo_sapiens 0 606

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