C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: high mobility group AT-hook 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000072777 Hmga2-001 ENSMUSG00000056758 10090 - 10:120361275-120476469 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000072777
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000072777 1.268±0.97 0.764±0.22 0.037±0.01 2.482±1.76 0.245±0.07 1.839±0.55 0.025±0.01 0.093±0.02 3.206±3.46 0.157±0.04 0.202±0.09 1.690±0.73 2.482±2.11

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00088X CIL_00088X_0002 VISTA 10:120251958-120853597

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000228 IDA nuclear chromosome
GO:0000975 ISS regulatory region DNA binding
GO:0001047 ISS core promoter binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001837 ISS epithelial to mesenchymal transition
GO:0002062 ISS chondrocyte differentiation
GO:0003131 ISS mesodermal-endodermal cell signaling
GO:0003680 ISS AT DNA binding
GO:0003906 ISS DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004677 ISS DNA-dependent protein kinase activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0006284 ISS base-excision repair
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0007067 IEA mitotic nuclear division
GO:0007095 ISS mitotic G2 DNA damage checkpoint
GO:0007165 IEA signal transduction
GO:0007283 IMP spermatogenesis
GO:0008283 IMP cell proliferation
GO:0008284 IMP positive regulation of cell proliferation
GO:0008301 ISS DNA binding, bending
GO:0008584 IMP male gonad development
GO:0010564 IDA regulation of cell cycle process
GO:0010628 IMP positive regulation of gene expression
GO:0019899 IEA enzyme binding
GO:0021846 IMP cell proliferation in forebrain
GO:0021983 IMP pituitary gland development
GO:0030261 IEA chromosome condensation
GO:0030325 IMP adrenal gland development
GO:0031052 ISS chromosome breakage
GO:0031492 ISS nucleosomal DNA binding
GO:0031507 ISS heterochromatin assembly
GO:0032993 ISS protein-DNA complex
GO:0033144 IEA negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0035019 IGI somatic stem cell maintenance
GO:0035497 ISS cAMP response element binding
GO:0035500 ISS MH2 domain binding
GO:0035501 ISS MH1 domain binding
GO:0035978 ISS histone H2A-S139 phosphorylation
GO:0035985 ISS senescence-associated heterochromatin focus
GO:0035986 ISS senescence-associated heterochromatin focus assembly
GO:0035987 ISS endodermal cell differentiation
GO:0035988 ISS chondrocyte proliferation
GO:0040018 IMP positive regulation of multicellular organism growth
GO:0042769 ISS DNA damage response, detection of DNA damage
GO:0043065 ISS positive regulation of apoptotic process
GO:0043066 ISS negative regulation of apoptotic process
GO:0043392 ISS negative regulation of DNA binding
GO:0043922 ISS negative regulation by host of viral transcription
GO:0045444 ISS fat cell differentiation
GO:0045869 ISS negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046426 IEA negative regulation of JAK-STAT cascade
GO:0048333 ISS mesodermal cell differentiation
GO:0048712 IDA negative regulation of astrocyte differentiation
GO:0048762 ISS mesenchymal cell differentiation
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051321 IEA meiotic cell cycle
GO:0051575 ISS 5'-deoxyribose-5-phosphate lyase activity
GO:0060123 IMP regulation of growth hormone secretion
GO:0060612 IMP adipose tissue development
GO:0060613 IGI fat pad development
GO:0070742 ISS C2H2 zinc finger domain binding
GO:0071141 ISS SMAD protein complex
GO:0071158 ISS positive regulation of cell cycle arrest
GO:0090276 IMP regulation of peptide hormone secretion
GO:0090402 ISS oncogene-induced cell senescence
GO:2000036 ISS regulation of stem cell maintenance
GO:2000648 ISS positive regulation of stem cell proliferation
GO:2000679 ISS positive regulation of transcription regulatory region DNA binding
GO:2000685 ISS positive regulation of cellular response to X-ray
GO:2000774 ISS positive regulation of cellular senescence
GO:2001022 ISS positive regulation of response to DNA damage stimulus
GO:2001033 ISS negative regulation of double-strand break repair via nonhomologous end joining
GO:2001038 ISS regulation of cellular response to drug

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000354636 HMGA2-008 protein_coding Homo_sapiens 0 544
ENST00000393577 HMGA2-013 protein_coding Homo_sapiens 0 470
ENST00000393578 HMGA2-005 protein_coding Homo_sapiens 0 544
ENST00000403681 HMGA2-001 protein_coding Homo_sapiens 0 1157
ENST00000425208 HMGA2-006 protein_coding Homo_sapiens 0 544
ENST00000536545 HMGA2-003 protein_coding Homo_sapiens 0 544
ENST00000537275 HMGA2-004 nonsense_mediated_decay Homo_sapiens 0 544
ENST00000537429 HMGA2-007 nonsense_mediated_decay Homo_sapiens 0 547
ENST00000539662 HMGA2-012 nonsense_mediated_decay Homo_sapiens 0 239
ENST00000541363 HMGA2-011 protein_coding Homo_sapiens 0 601
ENST00000545998 HMGA2-009 retained_intron Homo_sapiens 0 466

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