C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: nuclear receptor subfamily 1, group H, member 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000073488 Nr1h2-001 ENSMUSG00000060601 10090 - 7:44549616-44553949 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000073488
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000073488 14.620±1.01 32.199±5.49 13.396±1.37 8.840±1.56 21.777±5.29 24.686±1.97 6.919±4.22 21.170±4.18 7.214±2.23 17.163±7.54 9.530±1.92 22.253±6.25 11.267±4.84 8.731±3.56

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004IL CIL_0004IL_0002 CGP 7:44549616-44586862

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001133 IEA sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0008270 IEA zinc ion binding
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010867 IEA positive regulation of triglyceride biosynthetic process
GO:0010875 IDA positive regulation of cholesterol efflux
GO:0010884 IMP positive regulation of lipid storage
GO:0010887 IEA negative regulation of cholesterol storage
GO:0030522 IDA intracellular receptor signaling pathway
GO:0032270 IEA positive regulation of cellular protein metabolic process
GO:0032369 IEA negative regulation of lipid transport
GO:0032376 IEA positive regulation of cholesterol transport
GO:0034191 IEA apolipoprotein A-I receptor binding
GO:0042632 IDA cholesterol homeostasis
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044255 IDA cellular lipid metabolic process
GO:0045723 IEA positive regulation of fatty acid biosynthetic process
GO:0045861 IMP negative regulation of proteolysis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046965 IDA retinoid X receptor binding
GO:0048384 IEA retinoic acid receptor signaling pathway
GO:0048550 IEA negative regulation of pinocytosis
GO:0051006 IEA positive regulation of lipoprotein lipase activity
GO:0051117 IEA ATPase binding
GO:0055088 IMP lipid homeostasis
GO:0090108 IDA positive regulation of high-density lipoprotein particle assembly
GO:0090187 IMP positive regulation of pancreatic juice secretion
GO:0090340 IMP positive regulation of secretion of lysosomal enzymes
GO:2000188 IMP regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000253727 NR1H2-001 protein_coding Homo_sapiens 0 1387
ENST00000411902 NR1H2-003 protein_coding Homo_sapiens 0 1011
ENST00000593532 NR1H2-010 nonsense_mediated_decay Homo_sapiens 0 675
ENST00000593926 NR1H2-002 protein_coding Homo_sapiens 0 1358
ENST00000595730 NR1H2-007 retained_intron Homo_sapiens 0.000000002 68
ENST00000597085 NR1H2-013 retained_intron Homo_sapiens 0 641
ENST00000597130 NR1H2-008 protein_coding Homo_sapiens 0.000001 58
ENST00000597790 NR1H2-006 protein_coding Homo_sapiens 0.000001 58
ENST00000598168 NR1H2-014 protein_coding Homo_sapiens 0 712
ENST00000599105 NR1H2-005 protein_coding Homo_sapiens 0 675

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