C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear receptor subfamily 1, group H, member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000060601 Nr1h2 10090 - 7:44549616-44553951 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000073488 Nr1h2-001 44549616-44553949 protein_coding
  ENSMUST00000107910 Nr1h2-003 44549635-44553923 protein_coding
  ENSMUST00000107911 Nr1h2-002 44549617-44553948 protein_coding
  ENSMUST00000107912 Nr1h2-004 44549616-44553686 protein_coding
  ENSMUST00000123358 Nr1h2-006 44550302-44553911 retained_intron
  ENSMUST00000128354 Nr1h2-012 44550374-44551623 retained_intron
  ENSMUST00000128600 Nr1h2-008 44552494-44553923 retained_intron
  ENSMUST00000132769 Nr1h2-005 44551057-44553951 retained_intron
  ENSMUST00000136611 Nr1h2-009 44552634-44553899 retained_intron
  ENSMUST00000137674 Nr1h2-011 44551140-44551871 retained_intron
  ENSMUST00000141901 Nr1h2-007 44552209-44552587 retained_intron
  ENSMUST00000142298 Nr1h2-010 44552593-44553212 retained_intron
  ENSMUST00000167197 Nr1h2-201 44549652-44553923 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000073488ENSMUST00000107910ENSMUST00000107911ENSMUST00000107912ENSMUST00000123358ENSMUST00000128354ENSMUST00000132769
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000073488 14.620±1.01 32.199±5.49 13.396±1.37 8.840±1.56 21.777±5.29 24.686±1.97 6.919±4.22 21.170±4.18 7.214±2.23 17.163±7.54 9.530±1.92 22.253±6.25 11.267±4.84 8.731±3.56
ENSMUST00000107910 13.820±1.46 22.221±5.84 9.945±0.70 6.375±1.18 18.474±5.50 25.627±1.72 5.754±0.00 12.566±4.45 6.021±1.72 15.052±4.66 6.415±1.73 17.466±4.25 11.127±5.52 4.802±0.00
ENSMUST00000107911 8.270±0.50 N/A 9.879±0.54 4.224±0.00 8.363±2.03 15.812±0.96 8.013±1.81 10.214±1.87 8.434±2.36 10.361±1.43 4.570±1.35 13.400±2.53 8.055±1.49 5.823±0.15
ENSMUST00000107912 6.917±0.03 N/A N/A 11.026±7.98 8.546±0.00 N/A N/A N/A 3.708±0.00 8.551±0.57 N/A 21.724±13.13 18.366±1.01 4.046±0.23
ENSMUST00000123358 7.474±0.00 N/A 8.810±0.83 5.614±0.07 N/A N/A N/A N/A 4.530±0.84 N/A 3.195±0.00 11.397±2.71 10.976±2.25 0.854±0.00
ENSMUST00000128354 N/A N/A N/A 19.516±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 24.002±0.00 N/A
ENSMUST00000132769 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.764±0.01 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004IL CIL_0004IL_0002 CGP 7:44549616-44586862

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001133 IEA sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0008270 IEA zinc ion binding
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010867 IEA positive regulation of triglyceride biosynthetic process
GO:0010875 IDA positive regulation of cholesterol efflux
GO:0010884 IMP positive regulation of lipid storage
GO:0010887 IEA negative regulation of cholesterol storage
GO:0030522 IDA intracellular receptor signaling pathway
GO:0032270 IEA positive regulation of cellular protein metabolic process
GO:0032369 IEA negative regulation of lipid transport
GO:0032376 IEA positive regulation of cholesterol transport
GO:0034191 IEA apolipoprotein A-I receptor binding
GO:0042632 IDA cholesterol homeostasis
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044255 IDA cellular lipid metabolic process
GO:0045723 IEA positive regulation of fatty acid biosynthetic process
GO:0045861 IMP negative regulation of proteolysis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046965 IDA retinoid X receptor binding
GO:0048384 IEA retinoic acid receptor signaling pathway
GO:0048550 IEA negative regulation of pinocytosis
GO:0051006 IEA positive regulation of lipoprotein lipase activity
GO:0051117 IEA ATPase binding
GO:0055088 IMP lipid homeostasis
GO:0090108 IDA positive regulation of high-density lipoprotein particle assembly
GO:0090187 IMP positive regulation of pancreatic juice secretion
GO:0090340 IMP positive regulation of secretion of lysosomal enzymes
GO:2000188 IMP regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000131408 NR1H2 nuclear receptor subfamily 1, group H, member 2 protein_coding Homo_sapiens

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