C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: F-box and WD-40 domain protein 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000107679 Fbxw7-001 ENSMUSG00000028086 10090 + 3:84815268-84979198 protein_coding

Mus musculus EnsemblGRCm38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastKidneyLiverMuscleOvaryPlacentaTestisENSMUST00000107679
Transcript ID Adipose Bladder Brain Breast Kidney Liver Muscle Ovary Placenta Testis
ENSMUST00000107679 1.531±0.25 2.624±0.04 3.700±2.08 1.459±0.00 0.669±0.20 0.729±0.35 1.160±0.22 5.425±0.00 3.165±1.82 2.958±0.93

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00064N CIL_00064N_0002 CGP 3:84444035-85887516
CIL_0004PH CIL_0004PH_0002 CGP 3:84496093-85887516
CIL_0008CH CIL_0008CH_0002 VISTA 3:84637097-85239573

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001570 IMP vasculogenesis
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 IEA nucleoplasm
GO:0005730 IEA nucleolus
GO:0005737 TAS cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007062 IEA sister chromatid cohesion
GO:0007219 IDA Notch signaling pathway
GO:0016567 ISA protein ubiquitination
GO:0019005 IEA SCF ubiquitin ligase complex
GO:0030324 IMP lung development
GO:0030332 IEA cyclin binding
GO:0030674 IEA protein binding, bridging
GO:0031146 IBA SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032876 IEA negative regulation of DNA endoreduplication
GO:0034644 IEA cellular response to UV
GO:0042802 IEA identical protein binding
GO:0043234 IEA protein complex
GO:0045741 IEA positive regulation of epidermal growth factor-activated receptor activity
GO:0050821 IEA protein stabilization
GO:0051443 IEA positive regulation of ubiquitin-protein transferase activity
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0097027 IEA ubiquitin-protein transferase activator activity
GO:1901800 IEA positive regulation of proteasomal protein catabolic process
GO:1903378 IEA positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990452 IEA Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000060 IEA positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000086512 FBXW7-201 protein_coding Danio_rerio 0 1064
ENSDART00000148076 FBXW7-001 protein_coding Danio_rerio 0 1064
ENST00000263981 FBXW7-005 protein_coding Homo_sapiens 0 2409
ENST00000281708 FBXW7-001 protein_coding Homo_sapiens 0 3059
ENST00000296555 FBXW7-003 protein_coding Homo_sapiens 0 2403
ENST00000393956 FBXW7-007 protein_coding Homo_sapiens 0 2276
ENST00000603548 FBXW7-002 protein_coding Homo_sapiens 0 3061
ENST00000603821 FBXW7-008 retained_intron Homo_sapiens 0 553
ENST00000603841 FBXW7-012 protein_coding Homo_sapiens 0 3055
ENST00000604069 FBXW7-010 retained_intron Homo_sapiens 0 808
ENST00000604316 FBXW7-011 retained_intron Homo_sapiens 0 741
ENST00000604822 FBXW7-009 retained_intron Homo_sapiens 0 305
ENST00000604872 FBXW7-004 protein_coding Homo_sapiens 0 660
ENST00000605042 FBXW7-013 protein_coding Homo_sapiens 0 621

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