C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: adenomatous polyposis coli
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000257430 APC-001 ENSG00000134982 9606 + 5:112737888-112846239 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonKidneyLiverLungOvaryPlacentaTestisENST00000257430
Transcript ID Adrenal Brain Breast Colon Kidney Liver Lung Ovary Placenta Testis
ENST00000257430 2.241±0.00 14.871±7.58 1.419±0.00 4.594±0.00 2.026±0.00 2.027±0.00 1.832±0.00 1.617±0.61 1.431±0.00 2.821±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005KL CIL_0005KL_0002 CGP 5:112142441-112846239

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000281 IMP mitotic cytokinesis
GO:0000776 IDA kinetochore
GO:0001822 IEA kidney development
GO:0001942 IEA hair follicle development
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005881 IEA cytoplasmic microtubule
GO:0005886 IDA plasma membrane
GO:0005913 IDA cell-cell adherens junction
GO:0005923 IDA tight junction
GO:0006461 IDA protein complex assembly
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0006974 IEA:IDA cellular response to DNA damage stimulus
GO:0007026 IDA negative regulation of microtubule depolymerization
GO:0007050 IEA:IDA cell cycle arrest
GO:0007091 IEA metaphase/anaphase transition of mitotic cell cycle
GO:0007094 IMP mitotic spindle assembly checkpoint
GO:0007155 NAS cell adhesion
GO:0007389 IEA pattern specification process
GO:0007409 IEA axonogenesis
GO:0008013 IPI:IEA beta-catenin binding
GO:0008017 IDA:IEA microtubule binding
GO:0008285 IDA negative regulation of cell proliferation
GO:0009798 IEA axis specification
GO:0009952 IEA anterior/posterior pattern specification
GO:0009953 IEA dorsal/ventral pattern formation
GO:0009954 IEA proximal/distal pattern formation
GO:0016055 IEA Wnt signaling pathway
GO:0016328 IDA lateral plasma membrane
GO:0016477 IMP cell migration
GO:0019827 IEA stem cell maintenance
GO:0019887 IDA protein kinase regulator activity
GO:0019901 IPI protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0030334 IEA regulation of cell migration
GO:0030335 IMP positive regulation of cell migration
GO:0030424 IEA axon
GO:0030426 IEA growth cone
GO:0030856 IEA regulation of epithelial cell differentiation
GO:0030858 IEA positive regulation of epithelial cell differentiation
GO:0030877 IDA beta-catenin destruction complex
GO:0031116 IEA positive regulation of microtubule polymerization
GO:0031122 IEA cytoplasmic microtubule organization
GO:0031253 IEA cell projection membrane
GO:0031274 IMP positive regulation of pseudopodium assembly
GO:0032587 IDA ruffle membrane
GO:0032886 IMP regulation of microtubule-based process
GO:0033077 IEA T cell differentiation in thymus
GO:0035019 IEA somatic stem cell maintenance
GO:0035371 IEA microtubule plus-end
GO:0042483 IEA negative regulation of odontogenesis
GO:0042995 IEA cell projection
GO:0043065 IMP positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043409 IEA negative regulation of MAPK cascade
GO:0043588 IEA skin development
GO:0044295 IEA axonal growth cone
GO:0044336 IEA canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 IEA canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045295 IPI gamma-catenin binding
GO:0045595 IEA regulation of cell differentiation
GO:0045597 IEA positive regulation of cell differentiation
GO:0045667 IEA regulation of osteoblast differentiation
GO:0045670 IEA regulation of osteoclast differentiation
GO:0045732 IGI positive regulation of protein catabolic process
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785 IEA positive regulation of cell adhesion
GO:0046716 IEA muscle cell cellular homeostasis
GO:0048538 IEA thymus development
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051010 IDA microtubule plus-end binding
GO:0051171 IEA regulation of nitrogen compound metabolic process
GO:0051276 IEA chromosome organization
GO:0051726 IEA regulation of cell cycle
GO:0051781 IEA positive regulation of cell division
GO:0051988 NAS regulation of attachment of spindle microtubules to kinetochore
GO:0060041 IEA retina development in camera-type eye
GO:0060070 NAS canonical Wnt signaling pathway
GO:0060770 IEA negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070830 NAS tight junction assembly
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000115781 Apc-201 protein_coding Mus_musculus 0 10010
ENSMUST00000079362 Apc-001 protein_coding Mus_musculus 0 9830
ENSMUST00000171187 Apc-002 protein_coding Mus_musculus 0 3631
ENSMUST00000165590 Apc-006 nonsense_mediated_decay Mus_musculus 0 3044
ENSMUST00000170023 Apc-003 retained_intron Mus_musculus 0 1884
ENSMUST00000066133 Apc-005 protein_coding Mus_musculus 0 1033
ENSMUST00000167136 Apc-007 processed_transcript Mus_musculus 0 582
ENSMUST00000119356 Apc-ps1-001 transcribed_processed_pseudogene Mus_musculus 0 414
ENSMUST00000170195 Apc-004 retained_intron Mus_musculus 0 344
ENSDART00000044432 apc-201 protein_coding Danio_rerio 3e-22 113
ENSDART00000149956 apc-001 protein_coding Danio_rerio 3e-22 113

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