C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: EPH receptor A4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000281821 EPHA4-201 ENSG00000116106 9606 - 2:221418029-221572290 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000281821
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000281821 1.331±0.00 1.477±0.00 10.231±0.99 0.723±0.00 1.217±0.82 1.892±1.11 1.152±0.00 0.657±0.00 0.729±0.00 1.301±0.67 0.229±0.00 2.891±1.52

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006O4 CIL_0006O4_0001 CGP 2:219627327-221574202
CIL_0006XL CIL_0006XL_0001 CGP 2:221418027-222298996

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004672 IDA:IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005003 IEA ephrin receptor activity
GO:0005004 ISS GPI-linked ephrin receptor activity
GO:0005005 ISS transmembrane-ephrin receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 ISS cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 IEA plasma membrane
GO:0005887 ISS:IEA integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007155 IEA cell adhesion
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411 IEA axon guidance
GO:0007628 IEA adult walking behavior
GO:0008045 ISS motor neuron axon guidance
GO:0008347 IEA glial cell migration
GO:0009986 IEA cell surface
GO:0014069 IEA postsynaptic density
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA:IDA peptidyl-tyrosine phosphorylation
GO:0021957 ISS corticospinal tract morphogenesis
GO:0030054 IEA cell junction
GO:0030175 IEA filopodium
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0031594 IEA neuromuscular junction
GO:0031901 ISS early endosome membrane
GO:0032314 ISS regulation of Rac GTPase activity
GO:0032317 ISS regulation of Rap GTPase activity
GO:0032319 IEA regulation of Rho GTPase activity
GO:0042731 IPI PH domain binding
GO:0042802 IEA identical protein binding
GO:0042995 IEA cell projection
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0043679 IEA axon terminus
GO:0044295 IEA axonal growth cone
GO:0044297 IEA cell body
GO:0045211 IEA postsynaptic membrane
GO:0046777 IDA protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0048013 IEA ephrin receptor signaling pathway
GO:0048681 ISS negative regulation of axon regeneration
GO:0048710 ISS regulation of astrocyte differentiation
GO:0050770 ISS regulation of axonogenesis
GO:0050775 IEA positive regulation of dendrite morphogenesis
GO:0061001 ISS regulation of dendritic spine morphogenesis
GO:0097155 ISS fasciculation of sensory neuron axon
GO:0097156 ISS fasciculation of motor neuron axon
GO:0097161 IDA DH domain binding
GO:2001108 IDA positive regulation of Rho guanyl-nucleotide exchange factor activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000027451 Epha4-201 protein_coding Mus_musculus 0 4946
ENSMUST00000188952 Epha4-002 nonsense_mediated_decay Mus_musculus 0 4946
ENSMUST00000188797 Epha4-001 protein_coding Mus_musculus 0 4337
ENSMUST00000190149 Epha4-003 nonsense_mediated_decay Mus_musculus 0 3860
ENSMUST00000189934 Epha4-004 retained_intron Mus_musculus 0 2375
ENSMUST00000186930 Epha4-005 protein_coding Mus_musculus 0 562
ENSDART00000156185 ephb2a-201 protein_coding Danio_rerio 0 459
ENSDART00000148120 ephb2a-001 protein_coding Danio_rerio 0 459
ENSMUST00000187346 Epha4-006 protein_coding Mus_musculus 0 433
ENSDART00000050395 EPHB3 (2 of 2)-201 protein_coding Danio_rerio 0 348

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