C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: caspase 2, apoptosis-related cysteine peptidase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000310447 CASP2-001 ENSG00000106144 9606 + 7:143288215-143307696 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000310447
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000310447 3.236±0.00 3.934±0.00 0.576±0.00 1.919±0.00 2.410±0.29 1.029±0.00 3.879±0.00 0.562±0.00 2.547±1.24 0.548±0.00 6.152±4.04 5.998±2.33 5.018±0.45

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006VH CIL_0006VH_0001 CGP 7:143279957-143307696
CIL_0006VM CIL_0006VM_0001 CGP 7:143288215-143352083

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001554 IEA luteolysis
GO:0003407 IEA neural retina development
GO:0004197 IDA:IEA cysteine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005737 IBA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006508 IEA proteolysis
GO:0006915 NAS:IEA apoptotic process
GO:0006977 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007420 IEA brain development
GO:0007568 IEA aging
GO:0008234 IEA cysteine-type peptidase activity
GO:0008630 IBA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016020 IEA membrane
GO:0016485 IDA protein processing
GO:0019899 ISS enzyme binding
GO:0019904 IPI protein domain specific binding
GO:0035234 IEA ectopic germ cell programmed cell death
GO:0042981 IEA regulation of apoptotic process
GO:0043065 IDA positive regulation of apoptotic process
GO:0043281 TAS regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0071260 IEP cellular response to mechanical stimulus
GO:0097153 IEA cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 TAS apoptotic signaling pathway
GO:0097192 IBA extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194 TAS execution phase of apoptosis
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000031895 Casp2-001 protein_coding Mus_musculus 0 1568
ENSMUST00000156829 Casp2-003 nonsense_mediated_decay Mus_musculus 0 1074
ENSMUST00000139930 Casp2-004 retained_intron Mus_musculus 0 339
ENSMUST00000132246 Casp2-005 processed_transcript Mus_musculus 0 326
ENSMUST00000141669 Casp2-006 processed_transcript Mus_musculus 0 237
ENSMUST00000144821 Casp2-007 processed_transcript Mus_musculus 0 230
ENSMUST00000156289 Rgs20-006 retained_intron Mus_musculus 0.00002 57

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