C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info

Description: siah E3 ubiquitin protein ligase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000356721 SIAH1-001 ENSG00000196470 9606 - 16:48360531-48365901 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; PlacentaENST00000356721
Transcript ID Placenta
ENST00000356721 11.186±2.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002VR CIL_0002VR_0001 CGP 16:48244296-48448402

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS:IEA nucleus
GO:0005737 TAS cytoplasm
GO:0005769 IEA early endosome
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006508 TAS proteolysis
GO:0006511 IEA:IDA ubiquitin-dependent protein catabolic process
GO:0006915 TAS apoptotic process
GO:0007049 IEA cell cycle
GO:0007275 IEA multicellular organismal development
GO:0007283 IEA spermatogenesis
GO:0007399 TAS nervous system development
GO:0007411 TAS axon guidance
GO:0008022 IPI protein C-terminus binding
GO:0008270 IEA:ISS zinc ion binding
GO:0009653 TAS anatomical structure morphogenesis
GO:0016874 IEA ligase activity
GO:0030163 IDA protein catabolic process
GO:0030877 IDA beta-catenin destruction complex
GO:0031648 IEA protein destabilization
GO:0042787 ISS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043065 IDA positive regulation of apoptotic process
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051402 ISS neuron apoptotic process
GO:2001244 IMP positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000045296 Siah1a-201 protein_coding Mus_musculus 0 1893
ENSMUST00000071667 Siah1b-002 protein_coding Mus_musculus 0 1581
ENSMUST00000037928 Siah1b-001 protein_coding Mus_musculus 0 1581
ENSMUST00000070368 Siah2-001 protein_coding Mus_musculus 0 339
ENSMUST00000134272 Siah1b-003 protein_coding Mus_musculus 0 291
ENSMUST00000145032 Siah2-002 processed_transcript Mus_musculus 0 195

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