C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: FYVE, RhoGEF and PH domain containing 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000375135 FGD1-001 ENSG00000102302 9606 - X:54445454-54496166 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000375135
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000375135 4.249±0.00 2.588±0.00 0.612±0.00 1.079±0.00 1.828±1.22 2.110±1.35 1.545±1.34 3.342±0.00 0.577±0.00 1.416±1.13 0.938±0.00 5.237±3.00 4.669±0.77 6.829±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005737 ISS cytoplasm
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0007010 ISS cytoskeleton organization
GO:0007165 TAS signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007275 TAS multicellular organismal development
GO:0008360 ISS regulation of cell shape
GO:0009887 TAS organ morphogenesis
GO:0030027 ISS lamellipodium
GO:0030036 IDA actin cytoskeleton organization
GO:0031267 IDA small GTPase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043088 IDA regulation of Cdc42 GTPase activity
GO:0043547 IDA positive regulation of GTPase activity
GO:0046847 IDA filopodium assembly
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000026296 Fgd1-001 protein_coding Mus_musculus 0 4935
ENSMUST00000112685 Fgd1-002 protein_coding Mus_musculus 0 4076
ENSMUST00000026295 Tsr2-201 protein_coding Mus_musculus 0 815
ENSMUST00000112683 Tsr2-001 protein_coding Mus_musculus 0 815
ENSMUST00000125620 Fgd1-004 retained_intron Mus_musculus 0 590
ENSMUST00000124882 Fgd1-003 retained_intron Mus_musculus 0 228
ENSMUST00000024810 Fgd2-001 protein_coding Mus_musculus 0.000000003 69
ENSMUST00000123989 Fgd2-002 nonsense_mediated_decay Mus_musculus 0.000000003 69
ENSMUST00000137644 Fgd2-005 retained_intron Mus_musculus 0.00000004 66

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