C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: siah E3 ubiquitin protein ligase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000394725 SIAH1-002 ENSG00000196470 9606 - 16:48360531-48385450 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000394725
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000394725 12.857±0.00 10.999±0.00 12.725±0.00 12.249±0.00 9.569±0.00 5.675±0.00 9.900±0.00 9.019±0.00 8.764±0.00 10.899±3.45 11.362±2.05 17.868±6.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002VR CIL_0002VR_0001 CGP 16:48244296-48448402

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS:IEA nucleus
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0006508 TAS proteolysis
GO:0006511 IEA:IDA ubiquitin-dependent protein catabolic process
GO:0006915 TAS apoptotic process
GO:0007049 IEA cell cycle
GO:0007275 IEA multicellular organismal development
GO:0007283 IEA spermatogenesis
GO:0007399 TAS nervous system development
GO:0007411 TAS axon guidance
GO:0008022 IPI protein C-terminus binding
GO:0008270 IEA:ISS zinc ion binding
GO:0009653 TAS anatomical structure morphogenesis
GO:0016874 IEA ligase activity
GO:0030163 IDA protein catabolic process
GO:0030877 IDA beta-catenin destruction complex
GO:0042787 ISS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043065 IDA positive regulation of apoptotic process
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051402 ISS neuron apoptotic process
GO:2001244 IMP positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000045296 Siah1a-201 protein_coding Mus_musculus 0 1953
ENSMUST00000071667 Siah1b-002 protein_coding Mus_musculus 0 1596
ENSMUST00000037928 Siah1b-001 protein_coding Mus_musculus 0 1596
ENSMUST00000070368 Siah2-001 protein_coding Mus_musculus 0 339
ENSMUST00000134272 Siah1b-003 protein_coding Mus_musculus 0 305
ENSMUST00000145032 Siah2-002 processed_transcript Mus_musculus 0 195

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