C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD family member 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000439724 SMAD3-003 ENSG00000166949 9606 + 15:67138001-67190894 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; MusclePlacentaENST00000439724
Transcript ID Muscle Placenta
ENST00000439724 7.159±0.00 4.341±1.08

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008R9 CIL_0008R9_0001 VISTA 15:66606636-67207796
CIL_000471 CIL_000471_0002 CGP 15:66702228-67195195
CIL_0007L5 CIL_0007L5_0001 UCNEbase 15:66906943-67787880
CIL_00046Z CIL_00046Z_0002 CGP 15:67063763-67255195

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0000988 IDA protein binding transcription factor activity
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001666 IMP response to hypoxia
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005160 IPI transforming growth factor beta receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005637 IDA nuclear inner membrane
GO:0005654 TAS nucleoplasm
GO:0005667 IDA:IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 TAS transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006810 IDA transport
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 IMP immune response
GO:0007050 IMP cell cycle arrest
GO:0007179 IDA:IEA transforming growth factor beta receptor signaling pathway
GO:0007183 IDA SMAD protein complex assembly
GO:0008013 IPI beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008270 IDA zinc ion binding
GO:0010467 TAS gene expression
GO:0010628 IDA positive regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0017015 IMP regulation of transforming growth factor beta receptor signaling pathway
GO:0019049 IDA evasion or tolerance of host defenses by virus
GO:0019901 IPI protein kinase binding
GO:0019902 IPI phosphatase binding
GO:0030308 IDA negative regulation of cell growth
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030618 IDA transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031053 TAS primary miRNA processing
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032909 IMP regulation of transforming growth factor beta2 production
GO:0032924 IMP activin receptor signaling pathway
GO:0035326 IC enhancer binding
GO:0035413 IMP positive regulation of catenin import into nucleus
GO:0035556 IDA intracellular signal transduction
GO:0038092 IMP nodal signaling pathway
GO:0042060 TAS wound healing
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042803 IPI protein homodimerization activity
GO:0042993 IDA positive regulation of transcription factor import into nucleus
GO:0043130 IDA ubiquitin binding
GO:0043235 IMP receptor complex
GO:0043425 IPI bHLH transcription factor binding
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045216 IMP cell-cell junction organization
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045930 IMP negative regulation of mitotic cell cycle
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0050821 IMP protein stabilization
GO:0070410 IPI co-SMAD binding
GO:0070412 IPI R-SMAD binding
GO:0071141 IDA SMAD protein complex
GO:0071144 IDA SMAD2-SMAD3 protein complex
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:1901313 IDA positive regulation of gene expression involved in extracellular matrix organization

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034973 Smad3-001 protein_coding Mus_musculus 0 1555
ENSMUST00000154323 Smad3-002 protein_coding Mus_musculus 0 970
ENSDART00000044756 smad2-201 protein_coding Danio_rerio 0 758
ENSDART00000147653 smad2-002 protein_coding Danio_rerio 0 754
ENSDART00000121892 smad2-001 protein_coding Danio_rerio 0 754
ENSDART00000128579 smad2-202 protein_coding Danio_rerio 0 752
ENSMUST00000133108 Smad3-004 protein_coding Mus_musculus 0 582
ENSMUST00000137713 Smad3-005 protein_coding Mus_musculus 0 566
ENSMUST00000137065 Smad3-003 processed_transcript Mus_musculus 7e-36 156
ENSDART00000143608 smad2-004 protein_coding Danio_rerio 6e-27 126

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