C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: estrogen receptor 1 (alpha)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000105590 Esr1-001 ENSMUSG00000019768 10090 + 10:4611989-5005614 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000105590
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000105590 18.243±16.87 2.830±1.49 0.999±0.18 0.038±0.01 5.729±1.49 0.608±0.07 0.262±0.09 1.983±0.26 4.614±3.18 0.505±0.21 1.174±0.68 11.843±4.05 0.175±0.00 0.327±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005EH CIL_0005EH_0002 CGP 10:4482502-5005614
CIL_0005EI CIL_0005EI_0002 CGP 10:4611593-5550692

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001547 IMP antral ovarian follicle growth
GO:0002064 IMP epithelial cell development
GO:0003682 IDA chromatin binding
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 ISS steroid binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0007200 ISS phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0008013 IEA beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008209 IMP androgen metabolic process
GO:0008270 IEA zinc ion binding
GO:0008584 IMP male gonad development
GO:0010629 IEA negative regulation of gene expression
GO:0010863 ISS positive regulation of phospholipase C activity
GO:0016049 NAS cell growth
GO:0019899 IEA enzyme binding
GO:0030518 ISS intracellular steroid hormone receptor signaling pathway
GO:0032355 IEA response to estradiol
GO:0034056 IEA estrogen response element binding
GO:0035327 IEA transcriptionally active chromatin
GO:0038052 IEA estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0042802 IEA identical protein binding
GO:0042981 IMP regulation of apoptotic process
GO:0043124 ISS negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043433 ISS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043627 IEA response to estrogen
GO:0045429 ISS positive regulation of nitric oxide biosynthetic process
GO:0045839 NAS negative regulation of mitosis
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0048386 IEA positive regulation of retinoic acid receptor signaling pathway
GO:0051000 ISS positive regulation of nitric-oxide synthase activity
GO:0051091 ISS positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065 IGI uterus development
GO:0060068 IGI vagina development
GO:0060523 IMP prostate epithelial cord elongation
GO:0060527 IMP prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 IMP regulation of branching involved in prostate gland morphogenesis
GO:0060745 IMP mammary gland branching involved in pregnancy
GO:0060749 IMP mammary gland alveolus development
GO:0060750 IMP epithelial cell proliferation involved in mammary gland duct elongation
GO:0071391 IMP cellular response to estrogen stimulus
GO:0071392 ISS cellular response to estradiol stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000206249 ESR1-001 protein_coding Homo_sapiens 0 2239
ENST00000338799 ESR1-002 protein_coding Homo_sapiens 0 1949
ENST00000404742 ESR1-004 protein_coding Homo_sapiens 0 283
ENST00000406599 ESR1-009 protein_coding Homo_sapiens 0 575
ENST00000415488 ESR1-010 protein_coding Homo_sapiens 0 265
ENST00000427531 ESR1-008 protein_coding Homo_sapiens 0 1007
ENST00000440973 ESR1-201 protein_coding Homo_sapiens 0 2239
ENST00000443427 ESR1-202 protein_coding Homo_sapiens 0 2237
ENST00000446550 ESR1-007 protein_coding Homo_sapiens 0 374
ENST00000456483 ESR1-203 protein_coding Homo_sapiens 0 569
ENST00000482101 ESR1-003 processed_transcript Homo_sapiens 0 346
ENST00000488573 ESR1-006 processed_transcript Homo_sapiens 0 287

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