C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: thyroid hormone receptor, alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000450525 THRA-002 ENSG00000126351 9606 + 17:40062899-40092627 protein_coding

Homo sapiens EnsemblGRCh38

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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000450525
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000450525 9.402±0.00 3.791±0.00 1.218±0.00 7.255±3.90 12.836±0.00 15.524±0.00 5.223±4.30 3.376±3.07 1.594±0.06 3.531±3.15 8.412±7.26 7.725±5.09 5.544±0.79 5.030±2.59

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098Y CIL_00098Y_0001 VISTA 17:39768583-40372873
CIL_0002PX CIL_0002PX_0001 CGP 17:40015361-40061215
CIL_0002KL CIL_0002KL_0001 CGP 17:40019097-40093867
CIL_0002L8 CIL_0002L8_0001 CGP 17:40058290-40100725

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004887 IEA:IDA thyroid hormone receptor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 IDA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0008134 IPI transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0009755 IDA hormone-mediated signaling pathway
GO:0010467 TAS gene expression
GO:0017025 IDA TBP-class protein binding
GO:0017055 IDA negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0019904 IPI protein domain specific binding
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0070324 IDA thyroid hormone binding
GO:2000143 IDA negative regulation of DNA-templated transcription, initiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000103139 Thra-003 protein_coding Mus_musculus 0 2896
ENSMUST00000064187 Thra-001 protein_coding Mus_musculus 0 2375
ENSMUST00000124072 Thra-004 protein_coding Mus_musculus 0 1781
ENSMUST00000152195 Thra-002 processed_transcript Mus_musculus 0 985
ENSDART00000153187 thrab-001 protein_coding Danio_rerio 0 915
ENSDART00000000160 thraa-001 protein_coding Danio_rerio 0 891
ENSDART00000151127 thraa-002 protein_coding Danio_rerio 0 891
ENSDART00000074549 thrab-201 protein_coding Danio_rerio 0 881
ENSMUST00000153043 Thra-007 protein_coding Mus_musculus 0 632
ENSDART00000151575 thraa-003 retained_intron Danio_rerio 0 534
ENSMUST00000150693 Thra-006 processed_transcript Mus_musculus 0 394
ENSMUST00000153468 Thra-009 processed_transcript Mus_musculus 0 394
ENSMUST00000124130 Thra-008 processed_transcript Mus_musculus 2e-20 102

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