C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD family member 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000586040 SMAD2-004 ENSG00000175387 9606 - 18:47841225-47896811 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000586040
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000586040 19.784±0.00 8.224±0.00 7.175±1.37 10.963±5.00 13.581±7.82 6.061±0.96 5.672±3.45 5.851±3.27 9.697±0.00 7.426±4.90 9.347±4.79 10.039±1.60 15.862±6.37

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008OV CIL_0008OV_0001 VISTA 18:47242733-47843421
CIL_0008IS CIL_0008IS_0001 VISTA 18:47260919-47861703
CIL_0008FI CIL_0008FI_0001 VISTA 18:47646469-48247329
CIL_0008EL CIL_0008EL_0001 VISTA 18:47706836-48309090

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0001707 ISS mesoderm formation
GO:0003677 IDA DNA binding
GO:0003690 ISS double-stranded DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005160 IPI transforming growth factor beta receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA:IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 TAS transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007179 IDA:IEA transforming growth factor beta receptor signaling pathway
GO:0007182 IDA common-partner SMAD protein phosphorylation
GO:0007183 IDA SMAD protein complex assembly
GO:0007352 IMP zygotic specification of dorsal/ventral axis
GO:0007369 TAS gastrulation
GO:0008134 IPI transcription factor binding
GO:0009952 ISS anterior/posterior pattern specification
GO:0010467 TAS gene expression
GO:0010718 ISS positive regulation of epithelial to mesenchymal transition
GO:0017015 IMP regulation of transforming growth factor beta receptor signaling pathway
GO:0019902 IPI phosphatase binding
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 IMP positive regulation of BMP signaling pathway
GO:0030618 IDA transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031053 TAS primary miRNA processing
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032444 IDA activin responsive factor complex
GO:0032924 IMP activin receptor signaling pathway
GO:0033613 IPI activating transcription factor binding
GO:0034713 IPI type I transforming growth factor beta receptor binding
GO:0035326 IC enhancer binding
GO:0035556 ISS intracellular signal transduction
GO:0038092 IMP nodal signaling pathway
GO:0045165 ISS cell fate commitment
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IPI SMAD binding
GO:0046872 IEA metal ion binding
GO:0048340 ISS paraxial mesoderm morphogenesis
GO:0051098 ISS regulation of binding
GO:0060021 ISS palate development
GO:0070410 IPI co-SMAD binding
GO:0070411 IPI I-SMAD binding
GO:0070412 IPI R-SMAD binding
GO:0070723 IDA response to cholesterol
GO:0071141 IDA SMAD protein complex
GO:0071144 IDA SMAD2-SMAD3 protein complex
GO:1900224 IMP positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000168423 Smad2-001 protein_coding Mus_musculus 0 2052
ENSMUST00000025453 Smad2-002 protein_coding Mus_musculus 0 2030
ENSMUST00000091831 Smad2-003 protein_coding Mus_musculus 0 1868
ENSMUST00000113930 Smad2-004 protein_coding Mus_musculus 0 1650
ENSMUST00000172198 Smad2-006 protein_coding Mus_musculus 0 750
ENSMUST00000034973 Smad3-001 protein_coding Mus_musculus 0 686
ENSMUST00000165084 Smad2-007 protein_coding Mus_musculus 0 590
ENSMUST00000171256 Smad2-005 protein_coding Mus_musculus 0 545

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