C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD family member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000175387 SMAD2 9606 - 18:47808957-47931146 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262160 SMAD2-001 47808957-47930559 protein_coding
  ENST00000356825 SMAD2-201 47833096-47931146 protein_coding
  ENST00000402690 SMAD2-002 47831551-47931141 protein_coding
  ENST00000585978 SMAD2-009 47870475-47923642 protein_coding
  ENST00000586040 SMAD2-004 47841225-47896811 protein_coding
  ENST00000586487 SMAD2-010 47869422-47895725 processed_transcript
  ENST00000586514 SMAD2-005 47868327-47930837 protein_coding
  ENST00000587269 SMAD2-008 47868326-47930599 protein_coding
  ENST00000587353 SMAD2-011 47868263-47886923 processed_transcript
  ENST00000587421 SMAD2-007 47869352-47930362 protein_coding
  ENST00000589877 SMAD2-006 47870473-47930855 protein_coding
  ENST00000591214 SMAD2-003 47844912-47930842 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262160ENST00000356825ENST00000402690ENST00000586040ENST00000586514ENST00000591214
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262160 0.538±0.00 0.833±0.00 0.669±0.00 0.586±0.13 0.770±0.04 0.616±0.23 0.272±0.01 0.356±0.04 0.401±0.27 0.642±0.29 0.126±0.00 0.610±0.22 0.246±0.07 0.712±0.11
ENST00000356825 5.310±0.00 1.713±0.00 2.442±0.00 1.656±0.06 2.856±0.69 2.436±0.55 1.367±0.00 1.650±0.96 1.328±0.67 1.993±0.37 1.320±0.53 3.194±1.04 1.573±0.22 2.582±0.84
ENST00000402690 N/A N/A N/A N/A 0.996±0.00 1.576±0.00 0.820±0.00 0.468±0.00 1.301±0.00 2.846±0.00 N/A N/A N/A N/A
ENST00000586040 19.784±0.00 8.224±0.00 N/A 7.175±1.37 10.963±5.00 13.581±7.82 6.061±0.96 5.672±3.45 5.851±3.27 9.697±0.00 7.426±4.90 9.347±4.79 10.039±1.60 15.862±6.37
ENST00000586514 N/A N/A N/A 7.424±0.00 10.539±0.00 N/A 5.284±0.00 5.058±0.00 14.115±0.00 15.294±0.00 N/A N/A N/A N/A
ENST00000591214 N/A N/A N/A N/A N/A N/A N/A 2.635±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008OV CIL_0008OV_0001 VISTA 18:47242733-47843421
CIL_0008IS CIL_0008IS_0001 VISTA 18:47260919-47861703
CIL_0008FI CIL_0008FI_0001 VISTA 18:47646469-48247329
CIL_0008EL CIL_0008EL_0001 VISTA 18:47706836-48309090

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0001657 IEA ureteric bud development
GO:0001701 IEA in utero embryonic development
GO:0001706 IEA endoderm formation
GO:0001707 ISS mesoderm formation
GO:0003677 IDA DNA binding
GO:0003682 IEA chromatin binding
GO:0003690 ISS double-stranded DNA binding
GO:0003700 IEA:IDA sequence-specific DNA binding transcription factor activity
GO:0005160 IPI transforming growth factor beta receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA:IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA:TAS transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006468 IEA protein phosphorylation
GO:0007179 IDA:IEA transforming growth factor beta receptor signaling pathway
GO:0007182 IDA common-partner SMAD protein phosphorylation
GO:0007183 IDA SMAD protein complex assembly
GO:0007352 IMP zygotic specification of dorsal/ventral axis
GO:0007369 TAS gastrulation
GO:0007389 IEA pattern specification process
GO:0007492 IEA endoderm development
GO:0007507 IEA heart development
GO:0008134 IPI transcription factor binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009749 IEA response to glucose
GO:0009791 IEA post-embryonic development
GO:0009880 IEA embryonic pattern specification
GO:0009952 ISS anterior/posterior pattern specification
GO:0010467 TAS gene expression
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010718 ISS positive regulation of epithelial to mesenchymal transition
GO:0017015 IMP regulation of transforming growth factor beta receptor signaling pathway
GO:0019902 IPI phosphatase binding
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030073 IEA insulin secretion
GO:0030324 IEA lung development
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 IMP positive regulation of BMP signaling pathway
GO:0030618 IDA transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031016 IEA pancreas development
GO:0031053 TAS primary miRNA processing
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032444 IDA activin responsive factor complex
GO:0032924 IMP activin receptor signaling pathway
GO:0033613 IPI activating transcription factor binding
GO:0034713 IPI type I transforming growth factor beta receptor binding
GO:0035265 IEA organ growth
GO:0035326 IC enhancer binding
GO:0035556 ISS intracellular signal transduction
GO:0038092 IMP nodal signaling pathway
GO:0043234 IEA protein complex
GO:0045165 ISS cell fate commitment
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IPI SMAD binding
GO:0046872 IEA metal ion binding
GO:0048340 ISS paraxial mesoderm morphogenesis
GO:0048589 IEA developmental growth
GO:0048617 IEA embryonic foregut morphogenesis
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0051098 ISS regulation of binding
GO:0060021 ISS palate development
GO:0060039 IEA pericardium development
GO:0060395 IEA SMAD protein signal transduction
GO:0070410 IPI co-SMAD binding
GO:0070411 IPI I-SMAD binding
GO:0070412 IPI R-SMAD binding
GO:0070723 IDA response to cholesterol
GO:0071141 IDA SMAD protein complex
GO:0071144 IDA SMAD2-SMAD3 protein complex
GO:1900224 IMP positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006389 smad2 MAD homolog 2 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000024563 Smad2 SMAD family member 2 protein_coding Mus_musculus

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