C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neutral sphingomyelinase (N-SMase) activation associated factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000035681 NSMAF 9606 - 8:58583504-58659844 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000038176 NSMAF-001 58583504-58659844 protein_coding
  ENST00000427130 NSMAF-002 58583770-58659534 protein_coding
  ENST00000517612 NSMAF-010 58586349-58591009 retained_intron
  ENST00000518159 NSMAF-003 58623751-58659664 nonsense_mediated_decay
  ENST00000518229 NSMAF-004 58623747-58659638 nonsense_mediated_decay
  ENST00000519166 NSMAF-009 58589522-58594300 retained_intron
  ENST00000519174 NSMAF-014 58590866-58594747 retained_intron
  ENST00000519227 NSMAF-006 58597473-58600178 retained_intron
  ENST00000519858 NSMAF-012 58601168-58623419 processed_transcript
  ENST00000519871 NSMAF-017 58631428-58659214 retained_intron
  ENST00000521712 NSMAF-015 58586359-58589656 retained_intron
  ENST00000521972 NSMAF-011 58583809-58586578 retained_intron
  ENST00000522645 NSMAF-005 58631365-58659698 retained_intron
  ENST00000523106 NSMAF-007 58590001-58599480 retained_intron
  ENST00000523177 NSMAF-013 58587649-58595902 processed_transcript
  ENST00000523982 NSMAF-016 58597403-58600178 processed_transcript
  ENST00000524148 NSMAF-008 58589752-58594878 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000038176ENST00000427130ENST00000519227ENST00000519858ENST00000522645
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000038176 5.750±0.00 6.152±0.00 1.132±0.00 1.258±0.00 2.921±1.91 4.016±0.48 2.510±1.50 1.356±0.74 0.764±0.00 3.515±0.11 2.927±0.00 3.340±1.27 3.677±1.28 2.411±1.16
ENST00000427130 1.866±0.00 N/A N/A N/A 1.042±0.29 N/A 0.623±0.00 1.675±0.00 N/A N/A 0.798±0.00 N/A 1.045±0.22 0.805±0.00
ENST00000519227 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.668±0.00
ENST00000519858 N/A N/A 3.054±0.00 5.733±0.00 4.118±0.00 N/A N/A 1.367±0.00 7.217±0.00 6.001±0.00 8.037±0.00 8.263±0.00 N/A N/A
ENST00000522645 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.123±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002RG CIL_0002RG_0001 CGP 8:58552924-58659844
CIL_0008PQ CIL_0008PQ_0001 VISTA 8:58557235-59160028
CIL_0001SZ CIL_0001SZ_0001 CGP 8:58583504-59119208

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005057 TAS receptor signaling protein activity
GO:0005515 IPI:IEA protein binding
GO:0005737 TAS cytoplasm
GO:0006672 TAS ceramide metabolic process
GO:0007165 TAS signal transduction
GO:0016230 IEA sphingomyelin phosphodiesterase activator activity
GO:0035556 TAS intracellular signal transduction
GO:0043065 IEA positive regulation of apoptotic process
GO:0043085 IEA positive regulation of catalytic activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000051920 nsmaf neutral sphingomyelinase (N-SMase) activation associated factor protein_coding Danio_rerio
ENSMUSG00000028245 Nsmaf neutral sphingomyelinase (N-SMase) activation associated factor protein_coding Mus_musculus

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