C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: poly(A) binding protein, cytoplasmic 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000070756 PABPC1 9606 - 8:100685816-100722809 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000318607 PABPC1-001 100702916-100722712 protein_coding
  ENST00000517403 PABPC1-007 100706651-100712761 protein_coding
  ENST00000517921 PABPC1-010 100713138-100721583 retained_intron
  ENST00000517990 PABPC1-025 100703285-100706779 protein_coding
  ENST00000518196 PABPC1-020 100717817-100722036 protein_coding
  ENST00000518293 PABPC1-021 100685816-100704960 protein_coding
  ENST00000518716 PABPC1-022 100706703-100709847 retained_intron
  ENST00000519004 PABPC1-002 100703099-100722087 protein_coding
  ENST00000519100 PABPC1-012 100709459-100717890 protein_coding
  ENST00000519363 PABPC1-019 100721469-100722087 protein_coding
  ENST00000519596 PABPC1-013 100706694-100715601 processed_transcript
  ENST00000519622 PABPC1-024 100709136-100715496 nonsense_mediated_decay
  ENST00000519848 PABPC1-023 100704926-100707191 retained_intron
  ENST00000520142 PABPC1-008 100718120-100722092 protein_coding
  ENST00000520804 PABPC1-018 100721453-100722753 protein_coding
  ENST00000520868 PABPC1-006 100702916-100706931 protein_coding
  ENST00000521067 PABPC1-016 100721401-100722809 protein_coding
  ENST00000521865 PABPC1-015 100718087-100722749 protein_coding
  ENST00000522387 PABPC1-003 100703161-100721992 protein_coding
  ENST00000522658 PABPC1-005 100704114-100706974 protein_coding
  ENST00000522720 PABPC1-017 100718249-100722762 protein_coding
  ENST00000523555 PABPC1-009 100713142-100721566 protein_coding
  ENST00000523636 PABPC1-014 100703259-100712404 nonsense_mediated_decay
  ENST00000610907 PABPC1-201 100704298-100721508 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000318607ENST00000517403ENST00000518716ENST00000519004ENST00000519596ENST00000519622ENST00000520868ENST00000522387ENST00000523555ENST00000610907
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000318607 45.071±0.00 N/A 2.848±0.00 3.147±0.00 14.546±0.00 19.383±0.00 1.517±0.00 7.373±0.00 13.655±0.00 13.916±0.00 1.501±0.00 92.820±38.44 47.715±14.25 92.233±0.00
ENST00000517403 291.505±0.00 205.069±0.00 N/A 45.542±25.00 191.995±0.00 433.107±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000518716 N/A N/A 24.489±0.00 N/A N/A N/A 13.675±0.00 57.429±0.00 80.933±0.00 N/A N/A N/A N/A N/A
ENST00000519004 89.394±0.00 45.447±0.00 11.698±0.00 13.281±7.63 56.399±14.07 88.416±33.89 13.415±8.00 30.836±2.49 32.606±5.69 81.048±37.22 21.163±13.42 108.199±17.48 72.337±11.14 117.109±0.00
ENST00000519596 N/A N/A N/A N/A 51.146±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000519622 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2453.750±0.00 729.987±0.00 1545.130±0.00
ENST00000520868 N/A 76.471±0.00 N/A 22.026±0.00 75.810±0.00 162.247±0.00 27.541±0.00 48.755±0.00 45.025±0.00 141.260±0.00 40.931±0.00 N/A N/A 175.133±0.00
ENST00000522387 N/A 41.245±0.00 N/A N/A N/A N/A 17.635±0.00 26.322±0.00 16.610±0.00 89.725±0.00 N/A 96.263±0.00 39.904±1.47 N/A
ENST00000523555 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2056.190±0.00 595.398±0.00 1298.610±0.00
ENST00000610907 78.637±0.00 61.961±0.00 N/A N/A 46.459±0.00 N/A N/A 26.174±0.00 N/A N/A N/A 811.252±0.00 290.805±0.00 451.949±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0000184 TAS nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288 TAS nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 TAS nuclear-transcribed mRNA poly(A) tail shortening
GO:0000398 IC mRNA splicing, via spliceosome
GO:0003676 IEA nucleic acid binding
GO:0003723 IEA RNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0005925 IDA focal adhesion
GO:0006378 TAS mRNA polyadenylation
GO:0006412 TAS translation
GO:0006413 TAS translational initiation
GO:0008022 IPI protein C-terminus binding
GO:0008143 IDA poly(A) binding
GO:0008266 IDA poly(U) RNA binding
GO:0008494 TAS translation activator activity
GO:0010467 TAS gene expression
GO:0010494 IDA cytoplasmic stress granule
GO:0016020 IDA membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0030529 IDA ribonucleoprotein complex
GO:0031047 ISS gene silencing by RNA
GO:0036464 IDA cytoplasmic ribonucleoprotein granule
GO:0044267 TAS cellular protein metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0045727 TAS positive regulation of translation
GO:0048255 TAS mRNA stabilization
GO:0060213 ISS positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070062 IDA extracellular vesicular exosome
GO:0071013 IDA catalytic step 2 spliceosome
GO:1900153 ISS positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000623 IDA negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017219 pabpc1a poly A binding protein, cytoplasmic 1 a protein_coding Danio_rerio
ENSDARG00000021140 pabpc1b poly A binding protein, cytoplasmic 1 b protein_coding Danio_rerio
ENSMUSG00000051732 Pabpc2 poly(A) binding protein, cytoplasmic 2 protein_coding Mus_musculus

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