C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: scavenger receptor class B, member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000073060 SCARB1 9606 - 12:124776856-124882668 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261693 SCARB1-004 124777633-124863847 protein_coding
  ENST00000339570 SCARB1-001 124776856-124863917 protein_coding
  ENST00000415380 SCARB1-006 124777633-124863846 protein_coding
  ENST00000535005 SCARB1-003 124782683-124880461 processed_transcript
  ENST00000538291 SCARB1-005 124778278-124863863 retained_intron
  ENST00000539320 SCARB1-011 124814973-124863896 processed_transcript
  ENST00000541661 SCARB1-013 124814964-124882668 processed_transcript
  ENST00000544327 SCARB1-009 124785820-124817707 protein_coding
  ENST00000545305 SCARB1-010 124777873-124786493 processed_transcript
  ENST00000545493 SCARB1-012 124814961-124863863 protein_coding
  ENST00000546215 SCARB1-007 124778499-124863783 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261693ENST00000339570ENST00000415380ENST00000535005ENST00000538291ENST00000544327ENST00000545305ENST00000545493ENST00000546215
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261693 49.681±0.00 11.885±0.00 N/A 4.679±0.00 29.577±0.00 7.799±6.45 3.693±0.00 8.931±5.47 96.184±0.00 7.621±0.00 1.392±0.00 51.088±52.18 187.351±138.18 6.303±1.24
ENST00000339570 N/A N/A N/A 1.016±0.00 N/A N/A N/A 2.754±0.00 N/A N/A N/A N/A N/A N/A
ENST00000415380 N/A N/A N/A 3.552±0.00 N/A N/A N/A N/A N/A N/A 2.473±1.30 N/A N/A N/A
ENST00000535005 N/A N/A N/A 1.304±0.00 N/A N/A 0.353±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000538291 N/A 1.082±0.00 0.135±0.00 0.708±0.47 2.063±1.29 0.195±0.00 0.979±0.00 0.473±0.00 0.832±0.00 1.000±0.00 0.296±0.10 2.382±1.48 N/A 2.542±0.55
ENST00000544327 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.415±0.00 N/A 5.796±0.00
ENST00000545305 41.404±0.00 14.276±0.00 0.540±0.00 12.474±0.00 37.317±0.00 11.190±10.07 N/A 4.495±0.00 58.267±0.00 N/A N/A N/A N/A 16.478±0.00
ENST00000545493 N/A N/A N/A N/A N/A N/A N/A N/A 2.322±0.00 N/A N/A N/A N/A N/A
ENST00000546215 23.562±0.00 N/A 0.620±0.00 7.468±0.00 6.745±5.65 11.440±0.00 N/A 11.402±0.00 N/A 1.817±0.00 N/A 2.238±0.00 17.599±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000399 CIL_000399_0001 CGP 12:124324415-124882668
CIL_00006N CIL_00006N_0002 CGP 12:124776856-124917368

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001530 IDA lipopolysaccharide binding
GO:0001786 ISS phosphatidylserine binding
GO:0001875 IDA lipopolysaccharide receptor activity
GO:0001935 IEA endothelial cell proliferation
GO:0005215 TAS transporter activity
GO:0005515 IPI protein binding
GO:0005545 TAS 1-phosphatidylinositol binding
GO:0005737 IEA cytoplasm
GO:0005765 IDA lysosomal membrane
GO:0005886 IDA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005901 TAS caveola
GO:0006702 IEA androgen biosynthetic process
GO:0006707 IEA cholesterol catabolic process
GO:0006869 IEA lipid transport
GO:0006898 IDA receptor-mediated endocytosis
GO:0006910 IEA phagocytosis, recognition
GO:0007155 IEA cell adhesion
GO:0008035 IEA high-density lipoprotein particle binding
GO:0009986 IEA cell surface
GO:0010595 TAS positive regulation of endothelial cell migration
GO:0010867 ISS positive regulation of triglyceride biosynthetic process
GO:0010886 IDA positive regulation of cholesterol storage
GO:0010899 ISS regulation of phosphatidylcholine catabolic process
GO:0015914 ISS phospholipid transport
GO:0015920 IDA lipopolysaccharide transport
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016032 IEA viral process
GO:0030169 IDA low-density lipoprotein particle binding
GO:0030301 IEA cholesterol transport
GO:0030666 TAS endocytic vesicle membrane
GO:0031528 IEA microvillus membrane
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032497 IDA detection of lipopolysaccharide
GO:0033344 ISS cholesterol efflux
GO:0034185 IPI apolipoprotein binding
GO:0034186 IPI apolipoprotein A-I binding
GO:0034375 ISS high-density lipoprotein particle remodeling
GO:0034383 ISS low-density lipoprotein particle clearance
GO:0034384 IDA high-density lipoprotein particle clearance
GO:0042060 TAS wound healing
GO:0042157 TAS lipoprotein metabolic process
GO:0042632 ISS cholesterol homeostasis
GO:0042803 IEA protein homodimerization activity
GO:0043534 IEA blood vessel endothelial cell migration
GO:0043654 IDA recognition of apoptotic cell
GO:0043691 IEP reverse cholesterol transport
GO:0044281 TAS small molecule metabolic process
GO:0044406 IMP adhesion of symbiont to host
GO:0050764 IC regulation of phagocytosis
GO:0051000 IDA positive regulation of nitric-oxide synthase activity
GO:0070062 IDA extracellular vesicular exosome
GO:0070328 ISS triglyceride homeostasis
GO:0070506 IDA high-density lipoprotein particle receptor activity
GO:0070508 ISS cholesterol import

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042697 scarb1 scavenger receptor class B, member 1 protein_coding Danio_rerio
ENSMUSG00000037936 Scarb1 scavenger receptor class B, member 1 protein_coding Mus_musculus

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