C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rap guanine nucleotide exchange factor (GEF) 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000091428 RAPGEF4 9606 + 2:172735274-173052893 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000397081 RAPGEF4-001 172735841-173052887 protein_coding
  ENST00000397085 RAPGEF4-003 173026626-173036795 protein_coding
  ENST00000397087 RAPGEF4-004 172821575-173052893 protein_coding
  ENST00000409036 RAPGEF4-011 172735967-173052893 protein_coding
  ENST00000459852 RAPGEF4-008 172967109-172988273 processed_transcript
  ENST00000464976 RAPGEF4-009 172744138-172814740 processed_transcript
  ENST00000466030 RAPGEF4-006 172928152-172967397 processed_transcript
  ENST00000473003 RAPGEF4-013 172860038-172965638 processed_transcript
  ENST00000473043 RAPGEF4-010 172889801-172990925 processed_transcript
  ENST00000473182 RAPGEF4-007 172965141-172967316 retained_intron
  ENST00000484331 RAPGEF4-012 172735274-172917837 processed_transcript
  ENST00000484645 RAPGEF4-002 173048128-173051954 retained_intron
  ENST00000535187 RAPGEF4-201 172928205-173052887 protein_coding
  ENST00000538974 RAPGEF4-202 172860038-173052887 protein_coding
  ENST00000540783 RAPGEF4-203 172860038-173052887 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000397081ENST00000397085ENST00000397087ENST00000409036ENST00000466030ENST00000484645ENST00000535187ENST00000540783
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000397081 0.352±0.00 0.690±0.00 21.403±15.04 0.847±0.00 0.437±0.00 0.804±0.00 N/A N/A N/A N/A 1.449±0.69 N/A N/A
ENST00000397085 N/A N/A N/A N/A N/A N/A N/A 0.700±0.00 N/A N/A N/A N/A N/A
ENST00000397087 1.216±0.00 0.876±0.00 N/A 0.841±0.00 0.363±0.00 0.140±0.00 0.896±0.00 0.200±0.00 4.589±2.97 0.252±0.00 1.549±0.73 0.222±0.12 0.460±0.00
ENST00000409036 N/A N/A N/A N/A N/A 0.392±0.11 N/A N/A N/A N/A 3.815±0.00 N/A N/A
ENST00000466030 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 20.771±0.00 N/A N/A
ENST00000484645 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.519±0.00 N/A N/A N/A
ENST00000535187 N/A 1.490±0.00 N/A N/A 0.945±0.00 N/A N/A N/A N/A N/A 0.910±0.02 0.182±0.00 0.590±0.13
ENST00000540783 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.382±0.00 0.240±0.04 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004KA CIL_0004KA_0001 CGP 2:172555373-173052893
CIL_0003IJ CIL_0003IJ_0002 CGP 2:172735274-173268010

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 TAS:IEA guanyl-nucleotide exchange factor activity
GO:0005088 ISS Ras guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005829 IEA cytosol
GO:0005886 TAS plasma membrane
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0006112 TAS energy reserve metabolic process
GO:0007165 IEA signal transduction
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007596 TAS blood coagulation
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 TAS membrane
GO:0017016 ISS Ras GTPase binding
GO:0017156 IEA calcium ion-dependent exocytosis
GO:0017157 IEA regulation of exocytosis
GO:0019933 IEA cAMP-mediated signaling
GO:0030073 IEA insulin secretion
GO:0030168 TAS platelet activation
GO:0030552 ISS cAMP binding
GO:0032320 ISS positive regulation of Ras GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043547 TAS positive regulation of GTPase activity
GO:0044281 TAS small molecule metabolic process
GO:0045859 IEA regulation of protein kinase activity
GO:0050796 TAS regulation of insulin secretion
GO:0051056 IEA regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075924 Rap guanine nucleotide exchange factor (GEF) 4 protein_coding Danio_rerio
ENSMUSG00000049044 Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 protein_coding Mus_musculus

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