C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rap guanine nucleotide exchange factor (GEF) 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000049044 Rapgef4 10090 + 2:71981240-72257474 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028525 Rapgef4-005 72054604-72257472 protein_coding
  ENSMUST00000090826 Rapgef4-001 71981240-72257474 protein_coding
  ENSMUST00000102698 Rapgef4-003 71981287-72256376 protein_coding
  ENSMUST00000122975 Rapgef4-009 72140711-72196261 processed_transcript
  ENSMUST00000124004 Rapgef4-008 72054985-72141477 processed_transcript
  ENSMUST00000146970 Rapgef4-011 72242294-72256655 processed_transcript
  ENSMUST00000149421 Rapgef4-007 71981247-72034405 processed_transcript
  ENSMUST00000150234 Rapgef4-002 71981259-72141301 processed_transcript
  ENSMUST00000151236 Rapgef4-004 72140728-72163386 processed_transcript
  ENSMUST00000153887 Rapgef4-006 72179693-72257472 processed_transcript
  ENSMUST00000156031 Rapgef4-010 72198799-72208437 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028525ENSMUST00000090826ENSMUST00000102698ENSMUST00000122975ENSMUST00000146970ENSMUST00000153887
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028525 0.730±0.16 24.666±10.92 1.183±0.46 0.824±0.17 0.477±0.13 1.104±0.19 2.248±0.15 N/A 3.649±0.72 0.088±0.03 3.088±1.99 0.701±0.64 0.465±0.00
ENSMUST00000090826 0.687±0.14 6.776±0.00 3.918±0.79 N/A 0.149±0.00 1.845±0.34 N/A 0.368±0.04 0.626±0.00 N/A 1.420±0.32 0.169±0.08 0.372±0.00
ENSMUST00000102698 N/A N/A 91.311±0.00 N/A N/A N/A N/A N/A N/A 0.147±0.00 4.271±0.00 N/A 0.895±0.00
ENSMUST00000122975 N/A N/A 151.078±0.00 N/A N/A N/A N/A N/A N/A N/A 14.833±0.00 N/A N/A
ENSMUST00000146970 N/A 122.478±30.31 N/A N/A N/A N/A N/A N/A N/A N/A 17.237±0.00 N/A N/A
ENSMUST00000153887 N/A 13.479±1.77 16.229±15.33 N/A N/A N/A N/A 15.688±12.78 N/A 0.331±0.08 5.242±3.69 0.315±0.00 0.656±0.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004KA CIL_0004KA_0002 CGP 2:71873224-72257474
CIL_0003IJ CIL_0003IJ_0003 CGP 2:71981240-72442610

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005088 IDA Ras guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005829 IDA cytosol
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 IEA membrane
GO:0017016 IPI Ras GTPase binding
GO:0017156 IDA calcium ion-dependent exocytosis
GO:0017157 IDA regulation of exocytosis
GO:0019933 IDA cAMP-mediated signaling
GO:0030073 IDA insulin secretion
GO:0030552 IDA cAMP binding
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0043547 IEA positive regulation of GTPase activity
GO:0045859 IEA regulation of protein kinase activity
GO:0051056 IEA regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075924 Rap guanine nucleotide exchange factor (GEF) 4 protein_coding Danio_rerio
ENSG00000091428 RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 protein_coding Homo_sapiens

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