C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rap guanine nucleotide exchange factor (GEF) 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000397087 RAPGEF4-004 ENSG00000091428 9606 + 2:172821575-173052893 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000397087
Transcript ID Adipose Adrenal Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000397087 1.216±0.00 0.876±0.00 0.841±0.00 0.363±0.00 0.140±0.00 0.896±0.00 0.200±0.00 4.589±2.97 0.252±0.00 1.549±0.73 0.222±0.12 0.460±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004KA CIL_0004KA_0001 CGP 2:172555373-173052893
CIL_0003IJ CIL_0003IJ_0002 CGP 2:172735274-173268010

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005085 TAS:IEA guanyl-nucleotide exchange factor activity
GO:0005088 ISS Ras guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005886 TAS plasma membrane
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0006112 TAS energy reserve metabolic process
GO:0007165 IEA signal transduction
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007596 TAS blood coagulation
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 TAS membrane
GO:0017016 ISS Ras GTPase binding
GO:0030168 TAS platelet activation
GO:0030552 ISS cAMP binding
GO:0032320 ISS positive regulation of Ras GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043547 TAS positive regulation of GTPase activity
GO:0044281 TAS small molecule metabolic process
GO:0045859 IEA regulation of protein kinase activity
GO:0050796 TAS regulation of insulin secretion
GO:0051056 IEA regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000028525 Rapgef4-005 protein_coding Mus_musculus 0 3766
ENSMUST00000090826 Rapgef4-001 protein_coding Mus_musculus 0 3738
ENSMUST00000102698 Rapgef4-003 protein_coding Mus_musculus 0 3369
ENSMUST00000153887 Rapgef4-006 processed_transcript Mus_musculus 0 3181
ENSMUST00000122975 Rapgef4-009 processed_transcript Mus_musculus 0 915
ENSMUST00000156031 Rapgef4-010 processed_transcript Mus_musculus 0 545
ENSMUST00000146970 Rapgef4-011 processed_transcript Mus_musculus 0 342
ENSMUST00000124004 Rapgef4-008 processed_transcript Mus_musculus 5.99994e-41 174
ENSMUST00000150234 Rapgef4-002 processed_transcript Mus_musculus 6e-36 158

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