C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NLR family, pyrin domain containing 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000091592 NLRP1 9606 - 17:5499427-5619424 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262467 NLRP1-001 5501385-5584531 protein_coding
  ENST00000269280 NLRP1-010 5514127-5584448 protein_coding
  ENST00000345221 NLRP1-201 5514754-5584512 protein_coding
  ENST00000354411 NLRP1-012 5514754-5583957 protein_coding
  ENST00000544378 NLRP1-002 5499427-5584509 nonsense_mediated_decay
  ENST00000568641 NLRP1-004 5499439-5501145 processed_transcript
  ENST00000571307 NLRP1-007 5529895-5584512 processed_transcript
  ENST00000571451 NLRP1-008 5514122-5584479 nonsense_mediated_decay
  ENST00000572143 NLRP1-013 5584017-5619424 processed_transcript
  ENST00000572272 NLRP1-011 5514754-5583957 protein_coding
  ENST00000574406 NLRP1-003 5499428-5502963 processed_transcript
  ENST00000574512 NLRP1-005 5502292-5518565 retained_intron
  ENST00000576905 NLRP1-014 5583851-5619424 protein_coding
  ENST00000577119 NLRP1-009 5514754-5583957 protein_coding
  ENST00000613500 NLRP1-202 5501814-5584512 protein_coding
  ENST00000617618 NLRP1-203 5514754-5584512 protein_coding
  ENST00000619223 NLRP1-204 5514754-5584512 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262467ENST00000269280ENST00000345221ENST00000354411ENST00000544378ENST00000568641ENST00000571307ENST00000571451ENST00000572272ENST00000574512ENST00000577119ENST00000613500ENST00000617618
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262467 3.183±0.00 N/A N/A N/A 1.524±0.00 0.358±0.00 0.503±0.00 N/A N/A 1.987±0.06 N/A 1.225±0.00 1.421±0.23 N/A
ENST00000269280 2.125±0.00 N/A N/A N/A N/A 0.425±0.00 0.638±0.00 N/A 0.164±0.00 2.410±0.00 0.347±0.00 1.635±0.00 1.482±0.07 N/A
ENST00000345221 2.000±0.00 N/A N/A N/A N/A N/A N/A N/A 0.463±0.00 N/A N/A N/A N/A N/A
ENST00000354411 N/A N/A N/A N/A 1.273±0.00 N/A N/A 0.583±0.00 N/A 0.968±0.00 N/A N/A N/A N/A
ENST00000544378 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.137±0.00
ENST00000568641 N/A N/A N/A 114.600±61.19 N/A 6.341±0.00 N/A 3.772±0.00 0.562±0.00 11.285±0.00 N/A 37.319±32.82 10.640±1.54 32.388±0.31
ENST00000571307 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.144±0.00 N/A N/A N/A
ENST00000571451 N/A 7.104±0.00 0.225±0.00 N/A 1.407±0.94 0.577±0.00 0.227±0.00 0.154±0.00 0.564±0.12 1.277±0.00 N/A 0.574±0.00 N/A N/A
ENST00000572272 N/A 4.594±0.00 N/A N/A 0.889±0.31 0.775±0.00 0.480±0.08 N/A 0.433±0.00 N/A N/A 1.011±0.00 1.772±0.00 1.970±0.00
ENST00000574512 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.311±0.00 N/A N/A
ENST00000577119 N/A N/A 0.309±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000613500 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.479±0.00 N/A N/A
ENST00000617618 1.797±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002G8 CIL_0002G8_0001 CGP 17:5486285-5619424
CIL_0000N1 CIL_0000N1_0001 CGP 17:5499427-6124427

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA ATP binding
GO:0005622 IC intracellular
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0006915 NAS apoptotic process
GO:0006919 NAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008656 NAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899 IPI enzyme binding
GO:0019904 IPI protein domain specific binding
GO:0032495 ISS response to muramyl dipeptide
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042742 ISS defense response to bacterium
GO:0042981 IEA regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0050718 ISS positive regulation of interleukin-1 beta secretion
GO:0050727 IC regulation of inflammatory response
GO:0051402 IDA neuron apoptotic process
GO:0072558 IDA NLRP1 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000069830 Nlrp1a NLR family, pyrin domain containing 1A protein_coding Mus_musculus
ENSMUSG00000070390 Nlrp1b NLR family, pyrin domain containing 1B protein_coding Mus_musculus

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