C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: NLR family, pyrin domain containing 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000262467 NLRP1-001 ENSG00000091592 9606 - 17:5501385-5584531 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBreastColonHeartLungOvaryPlacentaENST00000262467
Transcript ID Adipose Breast Colon Heart Lung Ovary Placenta
ENST00000262467 3.183±0.00 1.524±0.00 0.358±0.00 0.503±0.00 1.987±0.06 1.225±0.00 1.421±0.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002G8 CIL_0002G8_0001 CGP 17:5486285-5619424
CIL_0000N1 CIL_0000N1_0001 CGP 17:5499427-6124427

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA ATP binding
GO:0005622 IC intracellular
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0006915 NAS apoptotic process
GO:0006919 NAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008656 NAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899 IPI enzyme binding
GO:0019904 IPI protein domain specific binding
GO:0032495 ISS response to muramyl dipeptide
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042742 ISS defense response to bacterium
GO:0045087 TAS innate immune response
GO:0050718 ISS positive regulation of interleukin-1 beta secretion
GO:0050727 IC regulation of inflammatory response
GO:0051402 IDA neuron apoptotic process
GO:0072558 IDA NLRP1 inflammasome complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000094046 Nlrp1b-201 protein_coding Mus_musculus 0 555
ENSMUST00000108516 Nlrp1b-001 protein_coding Mus_musculus 0 555
ENSMUST00000136493 Nlrp1b-003 nonsense_mediated_decay Mus_musculus 0 555
ENSMUST00000108514 Nlrp1b-202 protein_coding Mus_musculus 0 455
ENSMUST00000108515 Nlrp1b-002 protein_coding Mus_musculus 0 455
ENSMUST00000171546 Nlrp1c-ps-002 processed_transcript Mus_musculus 0 446
ENSMUST00000174668 Nlrp1c-ps-001 transcribed_unprocessed_pseudogene Mus_musculus 0 446

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