C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho/Rac guanine nucleotide exchange factor (GEF) 18
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104880 ARHGEF18 9606 + 19:7395113-7472477 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000319670 ARHGEF18-002 7395113-7472477 protein_coding
  ENST00000359920 ARHGEF18-001 7439688-7472477 protein_coding
  ENST00000594665 ARHGEF18-003 7447063-7472477 protein_coding
  ENST00000595600 ARHGEF18-005 7441719-7444429 retained_intron
  ENST00000599752 ARHGEF18-006 7395152-7441990 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000319670ENST00000594665ENST00000599752
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000319670 2.240±0.00 6.066±0.00 0.630±0.00 5.949±0.00 2.713±0.00 2.790±0.00 1.093±0.00 4.259±3.36 1.236±0.25 4.599±0.00 0.749±0.57 4.167±2.76 4.277±0.88 2.501±0.42
ENST00000594665 N/A 10.847±0.00 N/A 3.604±0.00 3.347±0.00 2.497±0.00 0.754±0.00 5.909±0.00 0.968±0.00 3.000±0.00 0.516±0.00 5.761±0.77 2.866±0.02 4.667±0.00
ENST00000599752 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.804±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004YI CIL_0004YI_0001 CGP 19:7348943-7472477
CIL_0002U4 CIL_0002U4_0001 CGP 19:7395113-7497449

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007264 IDA small GTPase mediated signal transduction
GO:0008360 IDA regulation of cell shape
GO:0030036 IDA actin cytoskeleton organization
GO:0030054 TAS cell junction
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 IDA positive regulation of GTPase activity
GO:0045177 IDA apical part of cell
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011157 arhgef18a rho/rac guanine nucleotide exchange factor (GEF) 18a protein_coding Danio_rerio
ENSDARG00000042308 arhgef18b rho/rac guanine nucleotide exchange factor (GEF) 18b protein_coding Danio_rerio
ENSMUSG00000004568 Arhgef18 rho/rac guanine nucleotide exchange factor (GEF) 18 protein_coding Mus_musculus

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