C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: actin, alpha 2, smooth muscle, aorta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000107796 ACTA2 9606 - 10:88935074-88991390 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000224784 ACTA2-001 88935074-88952773 protein_coding
  ENST00000415557 ACTA2-002 88941785-88991339 protein_coding
  ENST00000458159 ACTA2-003 88941785-88991288 protein_coding
  ENST00000458208 ACTA2-201 88935076-88991390 protein_coding
  ENST00000480297 ACTA2-006 88941001-88952747 processed_transcript
  ENST00000482085 ACTA2-004 88948242-88952773 processed_transcript
  ENST00000488967 ACTA2-005 88946820-88952773 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000224784ENST00000480297
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000224784 247.266±0.00 1046.020±0.00 14.679±0.00 21.065±13.70 256.316±74.65 443.515±313.59 48.897±26.26 132.740±125.46 306.229±258.71 392.149±335.37 102.044±65.32 502.267±427.23 766.020±366.91 547.593±435.83
ENST00000480297 N/A N/A 12.879±0.00 2.085±0.00 N/A N/A N/A N/A N/A N/A 18.514±0.00 25.434±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001RY CIL_0001RY_0001 CGP 10:88822132-88975153
CIL_0001IX CIL_0001IX_0001 CGP 10:88879734-88991390
CIL_0001VG CIL_0001VG_0001 CGP 10:88935074-89015785

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006936 TAS muscle contraction
GO:0008217 IEA regulation of blood pressure
GO:0009615 IEP response to virus
GO:0014829 IEA vascular smooth muscle contraction
GO:0015629 IEA actin cytoskeleton
GO:0019901 ISS protein kinase binding
GO:0030485 IEA smooth muscle contractile fiber
GO:0043234 IDA protein complex
GO:0070062 IDA extracellular vesicular exosome
GO:0072144 IEP glomerular mesangial cell development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045180 acta2 actin, alpha 2, smooth muscle, aorta protein_coding Danio_rerio
ENSDARG00000079111 ACTC1 (2 of 2) actin, alpha 2, smooth muscle, aorta protein_coding Danio_rerio
ENSMUSG00000035783 Acta2 actin, alpha 2, smooth muscle, aorta protein_coding Mus_musculus

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