C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: midkine (neurite growth-promoting factor 2)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000110492 MDK 9606 + 11:46380756-46383837 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359803 MDK-001 46381068-46383825 protein_coding
  ENST00000395565 MDK-201 46381711-46383837 protein_coding
  ENST00000395566 MDK-005 46381676-46383806 protein_coding
  ENST00000395569 MDK-004 46381669-46383825 protein_coding
  ENST00000405308 MDK-006 46380756-46383799 protein_coding
  ENST00000407067 MDK-002 46381753-46383783 protein_coding
  ENST00000441869 MDK-007 46380937-46382364 protein_coding
  ENST00000481047 MDK-009 46381711-46382770 retained_intron
  ENST00000489525 MDK-003 46381737-46383806 nonsense_mediated_decay
  ENST00000490240 MDK-008 46381061-46382821 retained_intron
  ENST00000533283 MDK-012 46381693-46383570 processed_transcript
  ENST00000533952 MDK-011 46381207-46382736 protein_coding
  ENST00000617138 MDK-202 46381655-46383837 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359803ENST00000395565ENST00000395566ENST00000395569ENST00000405308ENST00000489525ENST00000490240ENST00000533283ENST00000533952ENST00000617138
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359803 N/A N/A N/A N/A N/A N/A N/A 0.534±0.00 N/A N/A N/A N/A N/A
ENST00000395565 N/A N/A N/A N/A N/A 0.980±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000395566 20.349±0.00 5.879±0.00 N/A 11.347±6.27 10.240±7.60 1.542±0.56 12.981±0.00 N/A 42.804±0.00 1.081±0.00 300.796±290.21 49.940±23.25 13.072±0.00
ENST00000395569 N/A N/A 1.260±0.00 N/A N/A N/A N/A N/A N/A 2.210±0.00 N/A N/A N/A
ENST00000405308 5.516±0.00 3.489±0.00 N/A 1.092±0.00 3.523±0.00 1.215±0.00 N/A 1.201±0.00 1.242±0.00 0.983±0.00 N/A 6.433±0.00 N/A
ENST00000489525 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.674±0.00 N/A N/A
ENST00000490240 N/A N/A N/A 3.448±0.00 N/A N/A N/A 0.520±0.00 N/A N/A 3.427±0.00 N/A N/A
ENST00000533283 12.484±0.00 12.793±0.00 N/A 19.292±0.00 4.900±4.12 N/A 5.014±3.25 N/A 14.436±12.93 1.101±0.00 13.195±0.00 15.051±0.00 N/A
ENST00000533952 N/A N/A N/A 3.636±0.00 N/A N/A 0.880±0.00 N/A N/A N/A 22.790±0.00 23.073±0.00 N/A
ENST00000617138 N/A 3.394±0.00 N/A 7.861±0.00 7.997±0.00 N/A N/A 0.186±0.00 18.925±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002US CIL_0002US_0003 CGP 11:46332905-46383837
CIL_0002LJ CIL_0002LJ_0002 CGP 11:46380756-46386608

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001662 IEA behavioral fear response
GO:0005576 TAS extracellular region
GO:0005737 IEA cytoplasm
GO:0007165 NAS signal transduction
GO:0007219 TAS Notch signaling pathway
GO:0007399 NAS nervous system development
GO:0007614 IEA short-term memory
GO:0008083 IEA:NAS growth factor activity
GO:0008201 IDA heparin binding
GO:0009611 ISS response to wounding
GO:0009725 IEA response to hormone
GO:0016477 IEA cell migration
GO:0021542 IEA dentate gyrus development
GO:0021681 IEA cerebellar granular layer development
GO:0021766 IEA hippocampus development
GO:0021987 IEA cerebral cortex development
GO:0030154 NAS cell differentiation
GO:0030325 ISS adrenal gland development
GO:0030421 IEA defecation
GO:0042493 IEA response to drug
GO:0042995 IEA cell projection
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0050795 IEA regulation of behavior
GO:0051384 IEA response to glucocorticoid
GO:0051781 IEA positive regulation of cell division
GO:1901215 IEA negative regulation of neuron death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020708 mdkb midkine-related growth factor b protein_coding Danio_rerio
ENSDARG00000036036 mdka midkine-related growth factor protein_coding Danio_rerio
ENSMUSG00000027239 Mdk midkine protein_coding Mus_musculus

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