C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activating transcription factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115966 ATF2 9606 - 2:175072250-175168382 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264110 ATF2-001 175072250-175168206 protein_coding
  ENST00000345739 ATF2-013 175072250-175168206 protein_coding
  ENST00000392544 ATF2-002 175074505-175168169 protein_coding
  ENST00000409437 ATF2-011 175072265-175151082 protein_coding
  ENST00000409499 ATF2-014 175074505-175168169 protein_coding
  ENST00000409635 ATF2-012 175074280-175168203 protein_coding
  ENST00000409833 ATF2-009 175114243-175168169 protein_coding
  ENST00000413123 ATF2-017 175126793-175168144 processed_transcript
  ENST00000415955 ATF2-007 175074505-175168169 nonsense_mediated_decay
  ENST00000417080 ATF2-003 175074505-175168169 nonsense_mediated_decay
  ENST00000421438 ATF2-005 175074505-175168169 nonsense_mediated_decay
  ENST00000426833 ATF2-201 175072254-175168206 protein_coding
  ENST00000428760 ATF2-008 175074474-175168169 nonsense_mediated_decay
  ENST00000429579 ATF2-006 175074505-175168169 nonsense_mediated_decay
  ENST00000435004 ATF2-021 175074392-175130205 protein_coding
  ENST00000435231 ATF2-020 175111647-175168168 nonsense_mediated_decay
  ENST00000437522 ATF2-015 175113994-175168382 protein_coding
  ENST00000445349 ATF2-016 175126993-175168382 processed_transcript
  ENST00000456655 ATF2-004 175074505-175168169 nonsense_mediated_decay
  ENST00000478905 ATF2-018 175080263-175093254 retained_intron
  ENST00000538946 ATF2-202 175074288-175114812 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264110ENST00000345739ENST00000392544ENST00000409437ENST00000409833ENST00000426833ENST00000428760ENST00000435231ENST00000437522ENST00000456655ENST00000538946
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264110 5.145±0.00 1.778±0.00 N/A 7.764±2.18 4.410±0.00 2.120±0.48 1.197±0.00 1.182±0.00 2.081±0.00 N/A 2.483±0.00 4.582±1.84 1.989±0.43 10.836±0.00
ENST00000345739 N/A 1.633±0.00 0.796±0.00 N/A 1.663±0.00 2.885±1.02 N/A 4.495±0.00 3.149±0.00 1.868±0.30 0.950±0.00 1.627±0.05 1.206±0.21 N/A
ENST00000392544 N/A N/A N/A N/A N/A 2.701±0.00 0.796±0.00 2.318±0.00 2.855±0.00 5.171±0.00 N/A N/A N/A N/A
ENST00000409437 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.376±0.00 1.956±0.00 4.587±0.00
ENST00000409833 N/A N/A N/A N/A 1.733±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000426833 N/A 0.782±0.00 N/A 3.611±0.00 2.727±0.00 N/A 2.362±0.00 N/A 1.619±0.00 4.065±0.00 0.268±0.00 N/A N/A N/A
ENST00000428760 N/A N/A N/A N/A N/A 1.596±0.00 N/A N/A N/A N/A 1.340±0.00 2.267±0.00 N/A N/A
ENST00000435231 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.646±0.00 N/A N/A N/A
ENST00000437522 N/A N/A N/A N/A N/A N/A N/A 1.830±0.00 N/A N/A N/A N/A N/A N/A
ENST00000456655 N/A N/A 1.042±0.00 N/A 1.938±0.00 N/A 0.816±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000538946 N/A N/A 3.554±0.00 N/A N/A N/A N/A N/A N/A N/A 2.993±0.00 N/A N/A 8.953±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001HB CIL_0001HB_0001 CGP 2:174799363-175168382
CIL_0001H6 CIL_0001H6_0001 CGP 2:175072250-175184607

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000977 IMP RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001076 IC RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001228 IC RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003151 IEA outflow tract morphogenesis
GO:0003676 IEA nucleic acid binding
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0003705 IC RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 TAS transcription coactivator activity
GO:0004402 IDA histone acetyltransferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005741 IDA mitochondrial outer membrane
GO:0006325 TAS chromatin organization
GO:0006355 IMP:IEA regulation of transcription, DNA-templated
GO:0006357 IC regulation of transcription from RNA polymerase II promoter
GO:0006366 IC transcription from RNA polymerase II promoter
GO:0006970 IDA response to osmotic stress
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0008140 IDA cAMP response element binding protein binding
GO:0016020 IEA membrane
GO:0016573 IEA histone acetylation
GO:0019901 IPI protein kinase binding
GO:0031573 IMP intra-S DNA damage checkpoint
GO:0032915 IEA positive regulation of transforming growth factor beta2 production
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035497 IDA cAMP response element binding
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035861 IDA site of double-strand break
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0045087 TAS innate immune response
GO:0045444 IEA fat cell differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0051090 TAS regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0060612 IEA adipose tissue development
GO:1902110 IMP positive regulation of mitochondrial membrane permeability involved in apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000023903 atf2 activating transcription factor 2 protein_coding Danio_rerio
ENSMUSG00000027104 Atf2 activating transcription factor 2 protein_coding Mus_musculus

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