C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MCF.2 cell line derived transforming sequence-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000126217 MCF2L 9606 + 13:112894378-113099739 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261963 MCF2L-034 113087350-113098388 protein_coding
  ENST00000375597 MCF2L-003 113001754-113090183 protein_coding
  ENST00000375604 MCF2L-201 113001714-113099735 protein_coding
  ENST00000375608 MCF2L-001 112894378-113096861 protein_coding
  ENST00000397017 MCF2L-033 113074467-113098208 protein_coding
  ENST00000397021 MCF2L-007 113044662-113046855 protein_coding
  ENST00000397024 MCF2L-018 113001893-113027068 protein_coding
  ENST00000397030 MCF2L-002 112968500-113099739 protein_coding
  ENST00000397036 MCF2L-015 112902195-112910619 protein_coding
  ENST00000409954 MCF2L-030 113001270-113064311 protein_coding
  ENST00000413354 MCF2L-011 113086188-113096399 protein_coding
  ENST00000420013 MCF2L-010 113089636-113096832 protein_coding
  ENST00000421756 MCF2L-024 112979312-113096487 protein_coding
  ENST00000423251 MCF2L-023 113044851-113065303 protein_coding
  ENST00000433807 MCF2L-025 112985118-113024754 protein_coding
  ENST00000439475 MCF2L-012 113087796-113094604 protein_coding
  ENST00000441756 MCF2L-014 113089691-113095178 protein_coding
  ENST00000442625 MCF2L-016 112902195-112958164 nonsense_mediated_decay
  ENST00000453297 MCF2L-029 113087399-113097669 protein_coding
  ENST00000464800 MCF2L-009 113064312-113070394 retained_intron
  ENST00000469415 MCF2L-021 113093601-113098548 retained_intron
  ENST00000469558 MCF2L-022 113044462-113045322 processed_transcript
  ENST00000473345 MCF2L-008 113024698-113052753 protein_coding
  ENST00000475524 MCF2L-026 113064690-113075026 processed_transcript
  ENST00000480321 MCF2L-032 113040348-113047341 processed_transcript
  ENST00000486210 MCF2L-031 113001785-113024908 retained_intron
  ENST00000486806 MCF2L-019 113024664-113034137 protein_coding
  ENST00000487354 MCF2L-027 113084567-113086165 retained_intron
  ENST00000488765 MCF2L-020 113095222-113098546 retained_intron
  ENST00000491028 MCF2L-028 113090969-113094859 retained_intron
  ENST00000494043 MCF2L-006 113044688-113054905 processed_transcript
  ENST00000535094 MCF2L-005 112969221-113097074 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261963ENST00000375597ENST00000375604ENST00000397017ENST00000397030ENST00000397036ENST00000413354ENST00000421756ENST00000469415ENST00000488765ENST00000535094
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261963 16.212±0.00 3.333±0.00 N/A 14.405±0.00 4.391±2.41 7.295±0.00 5.649±0.00 8.437±0.00 0.921±0.06 1.953±0.00 N/A 2.267±0.99 2.013±1.30 1.416±0.00
ENST00000375597 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.699±0.00 N/A N/A
ENST00000375604 N/A N/A N/A N/A 1.009±0.32 0.505±0.00 N/A N/A 0.216±0.00 N/A N/A N/A N/A N/A
ENST00000397017 N/A 1.860±0.00 N/A 3.408±0.00 2.972±0.00 N/A 2.028±0.00 0.115±0.00 0.429±0.00 N/A 0.182±0.00 N/A N/A 0.707±0.00
ENST00000397030 N/A N/A N/A N/A N/A 1.711±0.00 N/A N/A N/A N/A N/A 0.456±0.00 N/A 0.411±0.00
ENST00000397036 N/A N/A N/A N/A N/A N/A N/A 5.845±0.00 N/A N/A N/A N/A N/A N/A
ENST00000413354 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.322±0.00
ENST00000421756 13.591±0.00 3.576±0.00 1.400±0.00 4.379±0.00 3.742±1.94 3.518±2.82 3.697±1.51 N/A 1.449±0.00 2.886±0.31 N/A 1.790±0.59 2.543±1.65 1.107±0.00
ENST00000469415 N/A N/A N/A 7.983±0.00 N/A 1.037±0.00 N/A N/A N/A 2.925±0.00 0.700±0.07 1.367±0.55 2.167±0.00 N/A
ENST00000488765 N/A 2.181±0.00 N/A N/A N/A N/A N/A 0.303±0.00 N/A N/A N/A 2.289±0.00 N/A N/A
ENST00000535094 N/A N/A N/A 17.141±0.00 N/A N/A N/A N/A N/A N/A 1.087±0.00 5.040±3.62 0.121±0.00 0.510±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00014E CIL_00014E_0001 CGP 13:112690329-113099739
CIL_0000RV CIL_0000RV_0001 CGP 13:112894378-113120681

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005545 IEA 1-phosphatidylinositol binding
GO:0005615 IDA extracellular space
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007266 IEA Rho protein signal transduction
GO:0016020 IEA membrane
GO:0030027 IEA lamellipodium
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075859 mcf2la mcf.2 cell line derived transforming sequence-like a protein_coding Danio_rerio
ENSDARG00000076480 mcf2lb mcf.2 cell line derived transforming sequence-like b protein_coding Danio_rerio
ENSMUSG00000031442 Mcf2l mcf.2 transforming sequence-like protein_coding Mus_musculus

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