C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate decarboxylase 1 (brain, 67kDa)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128683 GAD1 9606 + 2:170813213-170861151 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344257 GAD1-002 170816912-170842759 protein_coding
  ENST00000358196 GAD1-001 170816562-170861151 protein_coding
  ENST00000375272 GAD1-201 170816690-170842756 protein_coding
  ENST00000414527 GAD1-013 170817038-170859916 nonsense_mediated_decay
  ENST00000429023 GAD1-004 170818611-170844157 processed_transcript
  ENST00000445006 GAD1-008 170816114-170822116 protein_coding
  ENST00000454603 GAD1-007 170813213-170829585 protein_coding
  ENST00000455008 GAD1-009 170817255-170830991 protein_coding
  ENST00000456864 GAD1-010 170817769-170831008 protein_coding
  ENST00000462739 GAD1-014 170843802-170845543 retained_intron
  ENST00000478562 GAD1-006 170852488-170861147 retained_intron
  ENST00000485013 GAD1-011 170821718-170829620 retained_intron
  ENST00000486850 GAD1-015 170822087-170829872 protein_coding
  ENST00000488724 GAD1-005 170849067-170860253 retained_intron
  ENST00000493270 GAD1-012 170828968-170831090 retained_intron
  ENST00000493875 GAD1-003 170817770-170861151 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaENST00000344257ENST00000358196ENST00000414527ENST00000429023ENST00000478562ENST00000485013ENST00000488724ENST00000493270ENST00000493875
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta
ENST00000344257 N/A 0.219±0.00 N/A N/A 0.336±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000358196 0.007±0.00 N/A N/A 2.353±0.00 N/A N/A 0.011±0.00 0.359±0.00 N/A N/A N/A 0.061±0.00
ENST00000414527 N/A N/A 0.788±0.00 N/A N/A N/A N/A N/A N/A 0.112±0.00 N/A N/A
ENST00000429023 N/A N/A N/A N/A 0.072±0.00 N/A N/A N/A N/A 0.426±0.00 N/A N/A
ENST00000478562 N/A N/A N/A N/A 0.209±0.00 N/A 0.008±0.00 N/A 0.025±0.00 0.058±0.00 0.157±0.00 0.010±0.00
ENST00000485013 N/A N/A N/A N/A N/A N/A N/A N/A 0.119±0.00 N/A N/A N/A
ENST00000488724 N/A N/A N/A N/A N/A N/A 0.028±0.00 N/A 0.217±0.00 N/A N/A N/A
ENST00000493270 0.137±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.080±0.00
ENST00000493875 N/A 0.036±0.00 N/A N/A 0.024±0.00 0.022±0.00 N/A N/A N/A N/A 0.041±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003SB CIL_0003SB_0002 CGP 2:170783786-170861151
CIL_0003SC CIL_0003SC_0002 CGP 2:170813213-170967129

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004351 IDA glutamate decarboxylase activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005886 TAS plasma membrane
GO:0006520 IEA cellular amino acid metabolic process
GO:0006538 TAS glutamate catabolic process
GO:0006540 TAS glutamate decarboxylation to succinate
GO:0007268 TAS synaptic transmission
GO:0007269 TAS neurotransmitter secretion
GO:0008152 IEA metabolic process
GO:0009449 IEA gamma-aminobutyric acid biosynthetic process
GO:0012506 NAS vesicle membrane
GO:0016595 IEA glutamate binding
GO:0016829 IEA lyase activity
GO:0016831 IEA carboxy-lyase activity
GO:0018352 TAS protein-pyridoxal-5-phosphate linkage
GO:0019752 IEA carboxylic acid metabolic process
GO:0030170 IEA pyridoxal phosphate binding
GO:0042136 IEA neurotransmitter biosynthetic process
GO:0042493 IEA response to drug
GO:0046982 IEA protein heterodimerization activity
GO:0047485 IEA protein N-terminus binding
GO:0061202 TAS clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027419 gad1b glutamate decarboxylase 1b protein_coding Danio_rerio
ENSDARG00000093411 gad1a glutamate decarboxylase 1a protein_coding Danio_rerio
ENSMUSG00000070880 Gad1 glutamate decarboxylase 1 protein_coding Mus_musculus
ENSMUSG00000090665 Gad1-ps glutamate decarboxylase 1, pseudogene protein_coding Mus_musculus

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