C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arrestin, beta 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141480 ARRB2 9606 + 17:4710489-4721499 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000269260 ARRB2-002 4710489-4721471 protein_coding
  ENST00000346341 ARRB2-001 4710634-4721499 protein_coding
  ENST00000381488 ARRB2-009 4710693-4721061 protein_coding
  ENST00000412477 ARRB2-006 4710693-4721496 protein_coding
  ENST00000570718 ARRB2-012 4710632-4716539 processed_transcript
  ENST00000570739 ARRB2-011 4710632-4717941 processed_transcript
  ENST00000571206 ARRB2-008 4715589-4721138 protein_coding
  ENST00000571428 ARRB2-020 4710697-4719418 protein_coding
  ENST00000571791 ARRB2-014 4710682-4717062 retained_intron
  ENST00000572457 ARRB2-003 4710643-4721482 protein_coding
  ENST00000572497 ARRB2-016 4710691-4716515 nonsense_mediated_decay
  ENST00000572782 ARRB2-015 4714551-4716002 retained_intron
  ENST00000573886 ARRB2-018 4710691-4718370 retained_intron
  ENST00000574502 ARRB2-010 4710596-4719413 nonsense_mediated_decay
  ENST00000574888 ARRB2-013 4710655-4716473 retained_intron
  ENST00000574954 ARRB2-004 4710630-4721096 protein_coding
  ENST00000575131 ARRB2-017 4710661-4717379 retained_intron
  ENST00000575877 ARRB2-007 4710699-4721496 protein_coding
  ENST00000576235 ARRB2-021 4710724-4720407 nonsense_mediated_decay
  ENST00000577054 ARRB2-019 4717436-4718149 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000269260ENST00000346341ENST00000381488ENST00000412477ENST00000571206ENST00000571428ENST00000572457ENST00000574954ENST00000575131ENST00000575877ENST00000577054
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000269260 5.518±0.00 N/A N/A N/A 3.724±0.00 N/A 0.091±0.00 N/A N/A N/A N/A 9.838±5.16 5.951±0.37 3.684±0.00
ENST00000346341 5.564±0.00 N/A N/A 9.583±0.00 N/A N/A N/A N/A N/A N/A N/A 4.516±0.00 N/A N/A
ENST00000381488 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.507±0.00 N/A 2.659±0.00
ENST00000412477 N/A N/A N/A N/A N/A N/A 2.965±0.00 2.257±0.00 4.006±0.00 N/A 4.352±0.00 10.134±0.97 6.949±3.71 2.247±0.00
ENST00000571206 N/A N/A N/A N/A 1.466±0.00 N/A 0.218±0.00 N/A N/A 0.959±0.00 N/A N/A N/A N/A
ENST00000571428 N/A N/A 2.124±0.00 N/A N/A N/A 0.431±0.00 N/A 0.850±0.00 N/A N/A 12.320±0.00 10.691±0.00 N/A
ENST00000572457 16.858±0.00 29.989±0.00 0.797±0.00 14.514±11.10 7.874±5.67 17.449±0.00 9.113±0.00 10.424±0.00 5.759±4.60 42.437±0.00 6.010±0.00 4.778±0.00 19.894±2.35 8.244±0.00
ENST00000574954 N/A N/A N/A 2.773±0.00 N/A N/A N/A N/A N/A 0.928±0.00 N/A N/A 7.223±0.91 N/A
ENST00000575131 N/A N/A 1.482±0.00 N/A N/A N/A N/A N/A 1.506±0.00 N/A N/A N/A N/A N/A
ENST00000575877 N/A N/A N/A N/A N/A N/A 0.170±0.00 N/A N/A N/A 2.524±0.00 3.096±2.72 5.946±0.00 N/A
ENST00000577054 N/A N/A N/A N/A N/A 0.466±0.00 N/A N/A N/A 2.207±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PS CIL_0001PS_0001 CGP 17:4671385-4721499
CIL_000106 CIL_000106_0001 CGP 17:4710489-4733610

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 IPI G-protein coupled receptor binding
GO:0001932 IEA regulation of protein phosphorylation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002031 IDA G-protein coupled receptor internalization
GO:0002032 IMP desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092 IMP positive regulation of receptor internalization
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005905 IEA coated pit
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006897 IEA endocytosis
GO:0007165 IEA signal transduction
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007219 TAS Notch signaling pathway
GO:0007420 IEA brain development
GO:0007596 TAS blood coagulation
GO:0007628 IEA adult walking behavior
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0014069 IEA postsynaptic density
GO:0015031 IEA protein transport
GO:0016323 IEA basolateral plasma membrane
GO:0016567 IMP protein ubiquitination
GO:0019899 IPI enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030139 IDA endocytic vesicle
GO:0030168 TAS platelet activation
GO:0031397 IDA negative regulation of protein ubiquitination
GO:0031398 IGI positive regulation of protein ubiquitination
GO:0031410 IDA cytoplasmic vesicle
GO:0031623 IDA receptor internalization
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031691 IEA alpha-1A adrenergic receptor binding
GO:0031692 IEA alpha-1B adrenergic receptor binding
GO:0031701 IPI angiotensin receptor binding
GO:0031702 IEA type 1 angiotensin receptor binding
GO:0031748 IEA D1 dopamine receptor binding
GO:0031762 IEA follicle-stimulating hormone receptor binding
GO:0031826 IEA type 2A serotonin receptor binding
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032226 IEA positive regulation of synaptic transmission, dopaminergic
GO:0032403 IEA protein complex binding
GO:0032691 IEA negative regulation of interleukin-1 beta production
GO:0032695 IEA negative regulation of interleukin-12 production
GO:0032715 IEA negative regulation of interleukin-6 production
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0032947 IDA protein complex scaffold
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034122 IEA negative regulation of toll-like receptor signaling pathway
GO:0034260 IEA negative regulation of GTPase activity
GO:0034392 IEA negative regulation of smooth muscle cell apoptotic process
GO:0042699 IEA follicle-stimulating hormone signaling pathway
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 IEA dendritic spine
GO:0043422 IEA protein kinase B binding
GO:0045211 IEA postsynaptic membrane
GO:0045953 IMP negative regulation of natural killer cell mediated cytotoxicity
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0051019 IEA mitogen-activated protein kinase binding
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0051928 IEA positive regulation of calcium ion transport
GO:0060326 IMP cell chemotaxis
GO:0060765 IDA regulation of androgen receptor signaling pathway
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071889 IEA 14-3-3 protein binding
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:2000573 IEA positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011545 arrb2b arrestin, beta 2b protein_coding Danio_rerio
ENSDARG00000039215 arrb2a arrestin, beta 2a protein_coding Danio_rerio
ENSMUSG00000060216 Arrb2 arrestin, beta 2 protein_coding Mus_musculus

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