C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: arrestin, beta 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000412477 ARRB2-006 ENSG00000141480 9606 + 17:4710693-4721496 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartKidneyLiverMuscleOvaryPlacentaTestisENST00000412477
Transcript ID Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000412477 2.965±0.00 2.257±0.00 4.006±0.00 4.352±0.00 10.134±0.97 6.949±3.71 2.247±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PS CIL_0001PS_0001 CGP 17:4671385-4721499
CIL_000106 CIL_000106_0001 CGP 17:4710489-4733610

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001664 IPI G-protein coupled receptor binding
GO:0001932 IEA regulation of protein phosphorylation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002031 IDA G-protein coupled receptor internalization
GO:0002032 IMP desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092 IMP positive regulation of receptor internalization
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005905 IEA coated pit
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006897 IEA endocytosis
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007219 TAS Notch signaling pathway
GO:0007420 IEA brain development
GO:0007596 TAS blood coagulation
GO:0007628 IEA adult walking behavior
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0014069 IEA postsynaptic density
GO:0015031 IEA protein transport
GO:0016323 IEA basolateral plasma membrane
GO:0016567 IMP protein ubiquitination
GO:0019899 IPI enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030139 IDA endocytic vesicle
GO:0030168 TAS platelet activation
GO:0031397 IDA negative regulation of protein ubiquitination
GO:0031398 IGI positive regulation of protein ubiquitination
GO:0031410 IDA cytoplasmic vesicle
GO:0031623 IDA receptor internalization
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031691 IEA alpha-1A adrenergic receptor binding
GO:0031692 IEA alpha-1B adrenergic receptor binding
GO:0031701 IPI angiotensin receptor binding
GO:0031702 IEA type 1 angiotensin receptor binding
GO:0031748 IEA D1 dopamine receptor binding
GO:0031762 IEA follicle-stimulating hormone receptor binding
GO:0031826 IEA type 2A serotonin receptor binding
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032226 IEA positive regulation of synaptic transmission, dopaminergic
GO:0032403 IEA protein complex binding
GO:0032691 IEA negative regulation of interleukin-1 beta production
GO:0032695 IEA negative regulation of interleukin-12 production
GO:0032715 IEA negative regulation of interleukin-6 production
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0032947 IDA protein complex scaffold
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034122 IEA negative regulation of toll-like receptor signaling pathway
GO:0034260 IEA negative regulation of GTPase activity
GO:0034392 IEA negative regulation of smooth muscle cell apoptotic process
GO:0042699 IEA follicle-stimulating hormone signaling pathway
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 IEA dendritic spine
GO:0043422 IEA protein kinase B binding
GO:0045211 IEA postsynaptic membrane
GO:0045953 IMP negative regulation of natural killer cell mediated cytotoxicity
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0051019 IEA mitogen-activated protein kinase binding
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0051928 IEA positive regulation of calcium ion transport
GO:0060326 IMP cell chemotaxis
GO:0060765 IDA regulation of androgen receptor signaling pathway
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071889 IEA 14-3-3 protein binding
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:2000573 IEA positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000102564 Arrb2-007 protein_coding Mus_musculus 0 1077
ENSMUST00000102563 Arrb2-001 protein_coding Mus_musculus 0 1074
ENSMUST00000079056 Arrb2-005 protein_coding Mus_musculus 0 894
ENSMUST00000108568 Arrb2-013 protein_coding Mus_musculus 0 894
ENSMUST00000084954 Arrb2-006 protein_coding Mus_musculus 0 894
ENSMUST00000143232 Arrb2-002 retained_intron Mus_musculus 0 728
ENSMUST00000138006 Arrb2-012 retained_intron Mus_musculus 0 647
ENSMUST00000128748 Arrb2-011 nonsense_mediated_decay Mus_musculus 0 619
ENSMUST00000144454 Arrb2-003 retained_intron Mus_musculus 0 531
ENSMUST00000124943 Arrb2-009 protein_coding Mus_musculus 0 492
ENSMUST00000150076 Arrb2-010 protein_coding Mus_musculus 0 429
ENSMUST00000125441 Arrb2-004 retained_intron Mus_musculus 0 363
ENSMUST00000124112 Arrb2-008 retained_intron Mus_musculus 4e-24 117

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