C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arrestin, beta 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000060216 Arrb2 10090 + 11:70432635-70440828 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000079056 Arrb2-005 70432645-70440828 protein_coding
  ENSMUST00000084954 Arrb2-006 70432637-70440674 protein_coding
  ENSMUST00000102563 Arrb2-001 70432698-70440823 protein_coding
  ENSMUST00000102564 Arrb2-007 70432653-70440794 protein_coding
  ENSMUST00000108568 Arrb2-013 70432637-70440674 protein_coding
  ENSMUST00000124112 Arrb2-008 70432635-70435996 retained_intron
  ENSMUST00000124943 Arrb2-009 70432677-70437605 protein_coding
  ENSMUST00000125441 Arrb2-004 70436903-70438722 retained_intron
  ENSMUST00000128748 Arrb2-011 70432682-70438747 nonsense_mediated_decay
  ENSMUST00000138006 Arrb2-012 70436699-70440233 retained_intron
  ENSMUST00000143232 Arrb2-002 70437292-70439553 retained_intron
  ENSMUST00000144454 Arrb2-003 70438582-70440228 retained_intron
  ENSMUST00000150076 Arrb2-010 70432682-70436752 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000079056ENSMUST00000102563ENSMUST00000102564ENSMUST00000108568ENSMUST00000124943ENSMUST00000125441ENSMUST00000128748ENSMUST00000138006ENSMUST00000143232ENSMUST00000144454ENSMUST00000150076
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000079056 N/A 1.577±0.28 N/A N/A N/A 1.174±0.12 1.322±0.00 N/A N/A N/A N/A 2.492±0.76 N/A 1.165±0.00
ENSMUST00000102563 3.003±0.00 1.861±0.59 N/A 4.144±0.19 8.634±2.85 1.599±0.24 1.256±0.20 1.764±0.78 3.016±1.68 4.413±0.47 N/A 2.622±0.71 1.009±0.00 0.955±0.00
ENSMUST00000102564 4.637±1.64 2.128±0.33 3.923±0.14 8.120±0.13 5.095±2.46 1.387±0.49 1.416±0.51 3.222±1.26 5.892±4.00 5.292±0.88 2.700±1.17 3.990±3.28 3.707±1.78 0.775±0.27
ENSMUST00000108568 3.087±0.51 1.516±0.57 1.935±0.47 8.582±3.21 6.091±2.21 1.205±0.18 1.088±0.29 1.219±0.22 3.515±2.53 3.643±0.13 0.948±0.39 3.653±3.32 2.277±0.96 0.548±0.10
ENSMUST00000124943 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.491±1.53 0.579±0.00
ENSMUST00000125441 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.110±0.00 N/A N/A
ENSMUST00000128748 N/A 2.978±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000138006 5.083±1.45 3.251±0.19 N/A 5.609±0.12 N/A 2.423±0.42 1.452±0.41 N/A 0.873±0.00 6.416±0.76 N/A 2.497±0.33 N/A N/A
ENSMUST00000143232 9.824±3.38 5.219±0.15 N/A N/A 15.058±2.26 5.526±1.21 3.600±0.00 5.228±0.45 3.660±1.58 N/A N/A 9.715±2.72 N/A 2.426±0.03
ENSMUST00000144454 N/A 5.757±0.00 N/A N/A N/A 5.438±0.45 N/A 4.767±0.52 3.444±1.00 N/A N/A N/A N/A N/A
ENSMUST00000150076 N/A N/A N/A 41.519±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001PS CIL_0001PS_0002 CGP 11:70392883-70440828
CIL_000106 CIL_000106_0002 CGP 11:70432635-70453727

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 IEA G-protein coupled receptor binding
GO:0001932 IDA regulation of protein phosphorylation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002031 IEA G-protein coupled receptor internalization
GO:0002032 IEA desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092 ISS positive regulation of receptor internalization
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005886 IEA plasma membrane
GO:0005905 IEA coated pit
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006897 IEA endocytosis
GO:0007165 IEA signal transduction
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007420 IEA brain development
GO:0007628 IMP adult walking behavior
GO:0008277 IMP regulation of G-protein coupled receptor protein signaling pathway
GO:0014069 IEA postsynaptic density
GO:0015031 IEA protein transport
GO:0016323 IEA basolateral plasma membrane
GO:0016567 IEA protein ubiquitination
GO:0019899 IEA enzyme binding
GO:0019904 IEA protein domain specific binding
GO:0030139 ISS endocytic vesicle
GO:0031397 IEA negative regulation of protein ubiquitination
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031410 IEA cytoplasmic vesicle
GO:0031623 IEA receptor internalization
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031691 IEA alpha-1A adrenergic receptor binding
GO:0031692 IEA alpha-1B adrenergic receptor binding
GO:0031701 IEA angiotensin receptor binding
GO:0031702 IEA type 1 angiotensin receptor binding
GO:0031748 IEA D1 dopamine receptor binding
GO:0031762 IEA follicle-stimulating hormone receptor binding
GO:0031826 IEA type 2A serotonin receptor binding
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032226 IMP positive regulation of synaptic transmission, dopaminergic
GO:0032403 IEA protein complex binding
GO:0032691 IMP negative regulation of interleukin-1 beta production
GO:0032695 IMP negative regulation of interleukin-12 production
GO:0032715 IMP negative regulation of interleukin-6 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0032947 IEA protein complex scaffold
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034122 IMP negative regulation of toll-like receptor signaling pathway
GO:0034260 IEA negative regulation of GTPase activity
GO:0034392 IEA negative regulation of smooth muscle cell apoptotic process
GO:0042699 IEA follicle-stimulating hormone signaling pathway
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 IEA dendritic spine
GO:0043422 IPI protein kinase B binding
GO:0045211 IEA postsynaptic membrane
GO:0045953 IEA negative regulation of natural killer cell mediated cytotoxicity
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0051019 IEA mitogen-activated protein kinase binding
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0051928 IEA positive regulation of calcium ion transport
GO:0060326 IEA cell chemotaxis
GO:0060765 IEA regulation of androgen receptor signaling pathway
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071889 IEA 14-3-3 protein binding
GO:0090201 IEA negative regulation of release of cytochrome c from mitochondria
GO:2000573 IEA positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011545 arrb2b arrestin, beta 2b protein_coding Danio_rerio
ENSDARG00000039215 arrb2a arrestin, beta 2a protein_coding Danio_rerio
ENSG00000141480 ARRB2 arrestin, beta 2 protein_coding Homo_sapiens

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