C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000141837 CACNA1A 9606 - 19:13206442-13623990 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360228 CACNA1A-001 13206442-13506224 protein_coding
  ENST00000573710 CACNA1A-002 13207301-13506503 protein_coding
  ENST00000573891 CACNA1A-004 13231710-13255098 nonsense_mediated_decay
  ENST00000574822 CACNA1A-003 13229080-13253080 processed_transcript
  ENST00000574974 CACNA1A-006 13371761-13623990 protein_coding
  ENST00000585802 CACNA1A-012 13207301-13275896 protein_coding
  ENST00000586190 CACNA1A-011 13214440-13224956 retained_intron
  ENST00000587451 CACNA1A-008 13518975-13520257 processed_transcript
  ENST00000587525 CACNA1A-013 13206494-13257400 protein_coding
  ENST00000590205 CACNA1A-009 13261464-13262901 retained_intron
  ENST00000592864 CACNA1A-007 13518975-13599967 protein_coding
  ENST00000593160 CACNA1A-014 13334055-13365320 retained_intron
  ENST00000593267 CACNA1A-010 13234823-13235885 retained_intron
  ENST00000614285 CACNA1A-201 13206442-13506224 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000360228ENST00000573710ENST00000573891ENST00000574822ENST00000585802ENST00000586190ENST00000587525ENST00000590205ENST00000593160ENST00000614285
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000360228 0.100±0.00 N/A 0.018±0.00 3.734±0.00 N/A N/A N/A N/A 0.037±0.00 N/A 0.021±0.00 N/A 0.067±0.00 0.443±0.07
ENST00000573710 N/A 0.199±0.00 N/A 0.788±0.00 N/A 0.019±0.00 0.023±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000573891 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.090±0.00 N/A
ENST00000574822 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.258±0.16 N/A
ENST00000585802 N/A N/A N/A N/A N/A N/A N/A 0.036±0.00 0.030±0.00 0.030±0.00 N/A N/A N/A N/A
ENST00000586190 N/A N/A N/A N/A N/A N/A N/A 0.671±0.00 N/A N/A N/A N/A N/A N/A
ENST00000587525 0.219±0.00 0.443±0.00 N/A 4.445±0.00 0.254±0.00 N/A N/A N/A N/A N/A N/A 0.014±0.00 0.074±0.00 0.841±0.06
ENST00000590205 N/A N/A 0.410±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000593160 N/A N/A N/A N/A N/A 0.523±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000614285 N/A 0.164±0.00 N/A 1.274±0.93 N/A N/A N/A N/A N/A N/A 0.019±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VV CIL_0007VV_0001 VISTA 19:12752697-13356541
CIL_0007ZV CIL_0007ZV_0001 VISTA 19:12767682-13372012

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000096 IEA sulfur amino acid metabolic process
GO:0005216 IEA ion channel activity
GO:0005244 IEA voltage-gated ion channel activity
GO:0005245 ISS voltage-gated calcium channel activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005891 IEA voltage-gated calcium channel complex
GO:0006006 IEA glucose metabolic process
GO:0006112 TAS energy reserve metabolic process
GO:0006811 IEA ion transport
GO:0006816 IEA calcium ion transport
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0007214 IEA gamma-aminobutyric acid signaling pathway
GO:0007268 IBA synaptic transmission
GO:0007270 IEA neuron-neuron synaptic transmission
GO:0007274 IEA neuromuscular synaptic transmission
GO:0007416 IEA synapse assembly
GO:0007628 IEA adult walking behavior
GO:0008219 IDA cell death
GO:0008331 IBA high voltage-gated calcium channel activity
GO:0014051 IEA gamma-aminobutyric acid secretion
GO:0014056 IEA regulation of acetylcholine secretion, neurotransmission
GO:0016020 IEA membrane
GO:0016021 NAS integral component of membrane
GO:0016049 IEA cell growth
GO:0017156 IEA calcium ion-dependent exocytosis
GO:0017158 IEA regulation of calcium ion-dependent exocytosis
GO:0019226 IEA transmission of nerve impulse
GO:0019905 IDA syntaxin binding
GO:0021522 IEA spinal cord motor neuron differentiation
GO:0021590 IEA cerebellum maturation
GO:0021679 IEA cerebellar molecular layer development
GO:0021680 IEA cerebellar Purkinje cell layer development
GO:0021702 IEA cerebellar Purkinje cell differentiation
GO:0021750 IEA vestibular nucleus development
GO:0021953 IEA central nervous system neuron differentiation
GO:0030425 IEA dendrite
GO:0030644 IEA cellular chloride ion homeostasis
GO:0032353 IEA negative regulation of hormone biosynthetic process
GO:0034220 IEA ion transmembrane transport
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035249 IEA synaptic transmission, glutamatergic
GO:0042133 IEA neurotransmitter metabolic process
GO:0042391 IEA regulation of membrane potential
GO:0042445 IEA hormone metabolic process
GO:0042995 IDA cell projection
GO:0043025 IEA neuronal cell body
GO:0043113 IEA receptor clustering
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0048265 IEA response to pain
GO:0048266 IEA behavioral response to pain
GO:0048791 IEA calcium ion-dependent exocytosis of neurotransmitter
GO:0048813 IEA dendrite morphogenesis
GO:0050770 IEA regulation of axonogenesis
GO:0050796 TAS regulation of insulin secretion
GO:0050877 IEA neurological system process
GO:0050883 IEA musculoskeletal movement, spinal reflex action
GO:0050885 IEA neuromuscular process controlling balance
GO:0050905 IEA neuromuscular process
GO:0051899 TAS membrane depolarization
GO:0055085 IEA transmembrane transport
GO:0060024 IEA rhythmic synaptic transmission
GO:0070509 IBA calcium ion import
GO:0070588 IEA calcium ion transmembrane transport
GO:0086010 IBA membrane depolarization during action potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006923 cacna1ab calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b protein_coding Danio_rerio
ENSDARG00000037905 cacna1aa calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a protein_coding Danio_rerio
ENSMUSG00000034656 Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit protein_coding Mus_musculus

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