C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: RAB guanine nucleotide exchange factor (GEF) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000154710 RABGEF1 9606 + 7:66682164-66811464 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000284957 RABGEF1-001 66740733-66811464 protein_coding
  ENST00000380828 RABGEF1-201 66755882-66811459 protein_coding
  ENST00000437078 RABGEF1-202 66739975-66811459 protein_coding
  ENST00000439720 RABGEF1-003 66755889-66810667 protein_coding
  ENST00000442563 RABGEF1-005 66740733-66772035 protein_coding
  ENST00000450873 RABGEF1-002 66740733-66809817 protein_coding
  ENST00000461017 RABGEF1-006 66797372-66808064 processed_transcript
  ENST00000484547 RABGEF1-004 66771883-66811193 processed_transcript
  ENST00000510829 RABGEF1-203 66740656-66811459 protein_coding
  ENST00000607882 RABGEF1-007 66682164-66809662 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000439720ENST00000450873ENST00000607882
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000439720 N/A N/A 0.654±0.00 3.592±0.00 1.976±0.00 1.381±0.00 0.752±0.20 N/A 2.224±0.00 1.346±0.00 1.801±0.00 2.421±0.27 N/A N/A
ENST00000450873 N/A N/A N/A 1.979±0.00 2.300±0.00 N/A 1.136±0.27 1.972±0.00 2.673±1.64 2.726±0.89 N/A 3.285±0.85 2.969±0.36 9.129±0.93
ENST00000607882 4.174±0.00 4.765±0.00 0.529±0.00 3.766±1.65 4.829±0.00 5.556±0.00 1.701±0.66 0.704±0.00 1.440±0.41 3.034±0.00 2.735±0.00 5.980±3.80 4.139±1.49 15.318±5.45

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00024I CIL_00024I_0001 CGP 7:66205199-66811187
CIL_0005UP CIL_0005UP_0001 CGP 7:66628881-66811464
CIL_000256 CIL_000256_0001 CGP 7:66682164-66958551

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0002686 IEA negative regulation of leukocyte migration
GO:0003677 IEA DNA binding
GO:0004842 IEA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005769 IMP early endosome
GO:0006612 IMP protein targeting to membrane
GO:0006897 IEA endocytosis
GO:0008270 IEA zinc ion binding
GO:0016567 IEA protein ubiquitination
GO:0017112 IDA Rab guanyl-nucleotide exchange factor activity
GO:0017137 IPI Rab GTPase binding
GO:0031982 IEA vesicle
GO:0032851 IDA positive regulation of Rab GTPase activity
GO:0033004 IEA negative regulation of mast cell activation
GO:0043305 IEA negative regulation of mast cell degranulation
GO:0046580 IEA negative regulation of Ras protein signal transduction
GO:0048261 IEA negative regulation of receptor-mediated endocytosis
GO:0050728 IEA negative regulation of inflammatory response
GO:0060368 IEA regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165 IEA negative regulation of interleukin-6 secretion
GO:1900235 IEA negative regulation of Kit signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014430 rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 protein_coding Danio_rerio
ENSDARG00000015968 rabgef1l RAB guanine nucleotide exchange factor (GEF) 1, like protein_coding Danio_rerio
ENSMUSG00000025340 Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 protein_coding Mus_musculus

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