C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: RAB guanine nucleotide exchange factor (GEF) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025340 Rabgef1 10090 + 5:130171798-130214342 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026390 Rabgef1-002 130187161-130214337 protein_coding
  ENSMUST00000119027 Rabgef1-004 130187161-130208752 protein_coding
  ENSMUST00000119797 Rabgef1-001 130171798-130214342 protein_coding
  ENSMUST00000125937 Rabgef1-006 130207053-130210991 retained_intron
  ENSMUST00000143727 Rabgef1-005 130187220-130191321 retained_intron
  ENSMUST00000143865 Rabgef1-008 130213166-130214050 nonsense_mediated_decay
  ENSMUST00000147493 Rabgef1-007 130211381-130212975 retained_intron
  ENSMUST00000148264 Rabgef1-003 130171824-130210442 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000026390ENSMUST00000119797ENSMUST00000147493ENSMUST00000148264
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000026390 N/A 4.992±0.42 N/A N/A 4.294±1.94 5.219±0.27 N/A N/A 0.771±0.00 N/A N/A 4.872±1.05 N/A N/A
ENSMUST00000119797 3.467±0.26 1.647±0.00 14.219±3.44 3.720±1.00 4.016±1.85 5.812±0.16 3.680±1.51 4.338±0.97 6.634±2.45 9.066±1.66 16.913±3.44 3.698±1.16 7.076±3.12 2.402±0.51
ENSMUST00000147493 3.592±0.91 9.888±2.37 N/A 3.418±0.00 5.708±1.06 7.768±1.35 2.966±0.00 3.320±0.00 2.267±0.31 5.478±1.07 N/A 7.371±2.56 N/A 1.340±0.09
ENSMUST00000148264 N/A N/A N/A 8.469±0.00 N/A N/A N/A N/A N/A N/A N/A 15.748±0.00 14.097±4.84 1.248±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005UP CIL_0005UP_0002 CGP 5:130144861-130214342
CIL_000256 CIL_000256_0002 CGP 5:130171798-130243765

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0002686 IMP negative regulation of leukocyte migration
GO:0003677 IEA DNA binding
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005768 IEA endosome
GO:0005769 IEA early endosome
GO:0006612 IEA protein targeting to membrane
GO:0006897 IEA endocytosis
GO:0008270 IEA zinc ion binding
GO:0015031 IEA protein transport
GO:0016567 IDA protein ubiquitination
GO:0017112 IEA Rab guanyl-nucleotide exchange factor activity
GO:0017137 IEA Rab GTPase binding
GO:0031982 IDA vesicle
GO:0032851 IEA positive regulation of Rab GTPase activity
GO:0033004 IMP negative regulation of mast cell activation
GO:0043305 IMP negative regulation of mast cell degranulation
GO:0046580 IMP negative regulation of Ras protein signal transduction
GO:0048261 IMP negative regulation of receptor-mediated endocytosis
GO:0050728 IMP negative regulation of inflammatory response
GO:0060368 IMP regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165 IMP negative regulation of interleukin-6 secretion
GO:1900235 IMP negative regulation of Kit signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014430 rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 protein_coding Danio_rerio
ENSDARG00000015968 rabgef1l RAB guanine nucleotide exchange factor (GEF) 1, like protein_coding Danio_rerio
ENSG00000154710 RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 protein_coding Homo_sapiens

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