C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: brain-derived neurotrophic factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000176697 BDNF 9606 - 11:27654893-27722058 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000314915 BDNF-018 27654893-27722058 protein_coding
  ENST00000356660 BDNF-010 27654893-27700488 protein_coding
  ENST00000395978 BDNF-003 27654893-27720723 protein_coding
  ENST00000395980 BDNF-201 27654893-27701633 protein_coding
  ENST00000395981 BDNF-002 27654893-27720723 protein_coding
  ENST00000395983 BDNF-007 27654893-27701053 protein_coding
  ENST00000395986 BDNF-013 27654893-27699667 protein_coding
  ENST00000418212 BDNF-011 27654893-27700488 protein_coding
  ENST00000420794 BDNF-202 27654893-27701053 protein_coding
  ENST00000438929 BDNF-008 27654893-27701053 protein_coding
  ENST00000439476 BDNF-015 27654893-27659658 protein_coding
  ENST00000525528 BDNF-016 27654893-27659658 protein_coding
  ENST00000525950 BDNF-001 27654893-27720779 protein_coding
  ENST00000530786 BDNF-006 27654893-27701053 nonsense_mediated_decay
  ENST00000530861 BDNF-009 27654893-27700900 protein_coding
  ENST00000532997 BDNF-004 27654893-27719747 protein_coding
  ENST00000533131 BDNF-014 27654893-27699667 protein_coding
  ENST00000533246 BDNF-012 27654893-27700488 protein_coding
  ENST00000584049 BDNF-005 27654893-27701633 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000356660ENST00000395981ENST00000395983ENST00000438929ENST00000439476ENST00000525528ENST00000530786ENST00000530861ENST00000532997ENST00000533246ENST00000584049
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000356660 N/A N/A N/A N/A N/A N/A 0.363±0.00 N/A N/A N/A N/A 0.754±0.00 0.595±0.18 0.633±0.03
ENST00000395981 N/A N/A N/A 1.480±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000395983 0.058±0.00 N/A N/A N/A N/A 0.169±0.00 N/A 0.123±0.00 0.024±0.00 N/A 0.024±0.00 0.297±0.00 N/A N/A
ENST00000438929 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.201±0.00 N/A N/A N/A N/A
ENST00000439476 0.018±0.00 0.182±0.00 0.085±0.00 N/A N/A N/A 0.405±0.00 N/A N/A 0.088±0.00 N/A 0.029±0.00 N/A N/A
ENST00000525528 N/A N/A N/A N/A 0.205±0.00 N/A N/A N/A N/A N/A N/A 0.237±0.00 N/A N/A
ENST00000530786 N/A N/A 0.074±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.206±0.00 N/A
ENST00000530861 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.011±0.00 N/A N/A N/A
ENST00000532997 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.046±0.00 0.578±0.00 N/A
ENST00000533246 N/A N/A N/A N/A N/A 0.098±0.00 N/A 0.218±0.00 0.386±0.00 0.235±0.14 N/A N/A N/A N/A
ENST00000584049 N/A N/A N/A 0.812±0.14 N/A 0.071±0.00 0.566±0.00 N/A 0.484±0.00 N/A N/A N/A 0.258±0.11 0.197±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00078E CIL_00078E_0002 CGP 11:27494576-27722058
CIL_0004RP CIL_0004RP_0002 CGP 11:27654893-28108308

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001657 IEA ureteric bud development
GO:0001662 IEA behavioral fear response
GO:0001666 IEA response to hypoxia
GO:0002544 IEA chronic inflammatory response
GO:0005102 IEA receptor binding
GO:0005169 IEA neurotrophin TRKB receptor binding
GO:0005515 IEA protein binding
GO:0005576 IEA extracellular region
GO:0005615 IEA extracellular space
GO:0005737 ISS cytoplasm
GO:0006120 IEA mitochondrial electron transport, NADH to ubiquinone
GO:0007214 IEA gamma-aminobutyric acid signaling pathway
GO:0007399 TAS nervous system development
GO:0007406 IEA negative regulation of neuroblast proliferation
GO:0007411 IEA axon guidance
GO:0007412 IEA axon target recognition
GO:0007611 IEA learning or memory
GO:0007612 IEA learning
GO:0007623 IEA circadian rhythm
GO:0007631 IEA feeding behavior
GO:0008021 IEA synaptic vesicle
GO:0008038 IEA neuron recognition
GO:0008083 IEA growth factor activity
GO:0009416 IEA response to light stimulus
GO:0009642 IEA response to light intensity
GO:0009725 IEA response to hormone
GO:0010996 IEA response to auditory stimulus
GO:0014047 IEA glutamate secretion
GO:0014076 IEA response to fluoxetine
GO:0014823 IEA response to activity
GO:0016023 IEA cytoplasmic membrane-bounded vesicle
GO:0016358 IEA dendrite development
GO:0019222 IEA regulation of metabolic process
GO:0021675 IEA nerve development
GO:0030061 IEA mitochondrial crista
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0030516 IEA regulation of axon extension
GO:0031667 IEA response to nutrient levels
GO:0032094 IEA response to food
GO:0032229 IEA negative regulation of synaptic transmission, GABAergic
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0033189 IEA response to vitamin A
GO:0034612 IEA response to tumor necrosis factor
GO:0035864 IEA response to potassium ion
GO:0042490 IEA mechanoreceptor differentiation
GO:0042493 IEA response to drug
GO:0042596 IEA fear response
GO:0043025 IEA neuronal cell body
GO:0043066 IEA negative regulation of apoptotic process
GO:0043195 IEA terminal bouton
GO:0043204 IEA perikaryon
GO:0043523 IEA regulation of neuron apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045843 IEA negative regulation of striated muscle tissue development
GO:0046668 IEA regulation of retinal cell programmed cell death
GO:0048167 IEA regulation of synaptic plasticity
GO:0048169 IEA regulation of long-term neuronal synaptic plasticity
GO:0048170 IEA positive regulation of long-term neuronal synaptic plasticity
GO:0048172 IEA regulation of short-term neuronal synaptic plasticity
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048675 IEA axon extension
GO:0048839 IEA inner ear development
GO:0050890 IEA cognition
GO:0051602 IEA response to electrical stimulus
GO:0051965 IDA positive regulation of synapse assembly
GO:0055093 IEA response to hyperoxia
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0060548 IEA negative regulation of cell death
GO:0061193 IEA taste bud development
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071874 IEA cellular response to norepinephrine stimulus
GO:0072347 IEA response to anesthetic
GO:0097484 IEA dendrite extension
GO:1901215 IEA negative regulation of neuron death
GO:1902065 IEA response to L-glutamate
GO:1990089 IEA response to nerve growth factor
GO:1990090 IEA cellular response to nerve growth factor stimulus
GO:1990138 IEA neuron projection extension

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018817 bdnf brain-derived neurotrophic factor protein_coding Danio_rerio
ENSMUSG00000048482 Bdnf brain derived neurotrophic factor protein_coding Mus_musculus

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