C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) III alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000177302 TOP3A 9606 - 17:18271428-18315007 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000321105 TOP3A-001 18273967-18314993 protein_coding
  ENST00000461127 TOP3A-004 18302604-18314944 nonsense_mediated_decay
  ENST00000469739 TOP3A-003 18273967-18307159 retained_intron
  ENST00000472959 TOP3A-005 18306588-18314960 retained_intron
  ENST00000477508 TOP3A-006 18280175-18282813 retained_intron
  ENST00000489131 TOP3A-008 18272838-18274877 protein_coding
  ENST00000493648 TOP3A-007 18271428-18274958 nonsense_mediated_decay
  ENST00000542570 TOP3A-201 18273921-18315007 protein_coding
  ENST00000580095 TOP3A-020 18274804-18314703 protein_coding
  ENST00000580713 TOP3A-014 18308682-18314812 retained_intron
  ENST00000581536 TOP3A-012 18285428-18302361 nonsense_mediated_decay
  ENST00000582122 TOP3A-019 18282791-18290916 nonsense_mediated_decay
  ENST00000582230 TOP3A-017 18307526-18314969 processed_transcript
  ENST00000582981 TOP3A-009 18274724-18315007 nonsense_mediated_decay
  ENST00000583328 TOP3A-018 18306550-18314774 retained_intron
  ENST00000583804 TOP3A-013 18290557-18303090 retained_intron
  ENST00000584582 TOP3A-010 18274228-18314993 nonsense_mediated_decay
  ENST00000584669 TOP3A-011 18302686-18314930 processed_transcript
  ENST00000584887 TOP3A-016 18307532-18314970 processed_transcript
  ENST00000585031 TOP3A-015 18306934-18314974 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000321105ENST00000469739ENST00000542570ENST00000580095ENST00000582981ENST00000583328ENST00000583804ENST00000584582ENST00000585031
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000321105 N/A N/A N/A N/A 0.999±0.00 1.129±0.00 0.400±0.28 N/A 1.157±0.14 N/A 1.111±0.00 1.385±0.34 2.300±1.02 N/A
ENST00000469739 N/A N/A N/A N/A N/A 1.057±0.00 N/A N/A N/A N/A 0.168±0.00 2.605±0.00 2.229±0.00 N/A
ENST00000542570 1.128±0.00 3.064±0.00 N/A N/A N/A N/A N/A 0.919±0.00 N/A 1.034±0.00 N/A 0.738±0.00 N/A N/A
ENST00000580095 N/A N/A N/A N/A 0.402±0.00 N/A N/A 0.392±0.00 1.386±0.00 N/A N/A 2.021±0.33 2.857±0.00 3.565±2.37
ENST00000582981 N/A N/A N/A N/A N/A N/A N/A 0.883±0.00 N/A N/A N/A N/A N/A 1.414±0.00
ENST00000583328 N/A N/A 1.341±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000583804 N/A N/A N/A N/A 0.785±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000584582 0.946±0.00 N/A N/A 1.301±0.00 N/A 1.049±0.00 N/A 1.900±0.00 0.771±0.00 N/A N/A 1.348±0.00 1.564±0.00 2.921±0.78
ENST00000585031 N/A N/A N/A N/A N/A N/A 1.427±0.00 N/A N/A N/A 0.615±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005K3 CIL_0005K3_0001 CGP 17:18260534-18315007
CIL_00002B CIL_00002B_0002 CGP 17:18271428-18323203

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003677 IEA DNA binding
GO:0003916 IEA DNA topoisomerase activity
GO:0003917 IDA DNA topoisomerase type I activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005694 IEA chromosome
GO:0006265 IDA:IEA DNA topological change
GO:0007126 TAS meiotic nuclear division
GO:0008270 IEA zinc ion binding
GO:0016605 IDA PML body

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052827 top3a topoisomerase (DNA) III alpha protein_coding Danio_rerio
ENSMUSG00000002814 Top3a topoisomerase (DNA) III alpha protein_coding Mus_musculus

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