C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) III alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000002814 Top3a 10090 - 11:60740058-60777365 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000002891 Top3a-002 60740058-60777365 protein_coding
  ENSMUST00000102668 Top3a-003 60741891-60777265 protein_coding
  ENSMUST00000117743 Top3a-001 60740059-60777287 protein_coding
  ENSMUST00000120417 Top3a-006 60742234-60777264 protein_coding
  ENSMUST00000124799 Top3a-005 60749457-60752678 retained_intron
  ENSMUST00000130068 Top3a-004 60761732-60777299 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000002891ENSMUST00000102668ENSMUST00000117743ENSMUST00000120417
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000002891 2.049±0.26 1.505±0.63 3.138±0.10 2.831±1.67 2.848±0.35 2.924±0.62 0.707±0.30 1.946±0.45 2.566±1.45 2.709±0.26 0.732±0.27 3.369±1.38 4.031±0.97 6.488±1.43
ENSMUST00000102668 0.867±0.39 1.248±0.56 N/A N/A 0.860±0.08 0.719±0.00 0.263±0.01 0.553±0.00 0.442±0.13 N/A N/A 3.179±0.09 0.824±0.39 1.315±0.00
ENSMUST00000117743 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.299±0.00 2.134±0.60 N/A N/A
ENSMUST00000120417 N/A N/A N/A 0.526±0.00 N/A N/A 0.633±0.00 N/A N/A N/A 0.345±0.00 1.359±0.00 2.528±0.59 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005K3 CIL_0005K3_0002 CGP 11:60728398-60777365
CIL_00002B CIL_00002B_0003 CGP 11:60740058-60788287

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0003917 ISS DNA topoisomerase type I activity
GO:0005515 IEA protein binding
GO:0005654 TAS nucleoplasm
GO:0005694 IEA chromosome
GO:0006265 ISS DNA topological change
GO:0008270 IEA zinc ion binding
GO:0016605 IEA PML body

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052827 top3a topoisomerase (DNA) III alpha protein_coding Danio_rerio
ENSG00000177302 TOP3A topoisomerase (DNA) III alpha protein_coding Homo_sapiens

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