C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Pbx/knotted 1 homeobox
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000006705 Pknox1 10090 + 17:31564749-31607684 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000097352 Pknox1-001 31564801-31607680 protein_coding
  ENSMUST00000175709 Pknox1-005 31591732-31592158 processed_transcript
  ENSMUST00000175806 Pknox1-003 31564749-31605481 protein_coding
  ENSMUST00000175812 Pknox1-006 31594821-31599601 retained_intron
  ENSMUST00000176513 Pknox1-007 31602738-31603584 retained_intron
  ENSMUST00000176701 Pknox1-004 31583552-31607684 protein_coding
  ENSMUST00000176895 Pknox1-002 31564759-31590076 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000097352ENSMUST00000175806ENSMUST00000176701ENSMUST00000176895
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000097352 5.560±2.04 3.493±0.39 5.786±0.11 6.816±3.41 4.937±0.89 3.393±1.12 2.015±0.35 4.324±0.71 3.178±0.70 4.655±0.73 2.236±0.24 6.016±1.22 5.709±0.75 6.603±2.42
ENSMUST00000175806 4.181±2.16 3.326±0.42 1.782±0.00 N/A 4.095±0.34 4.484±0.66 1.229±0.20 2.309±0.60 1.574±0.56 3.856±0.48 N/A 9.835±1.82 2.178±0.02 6.546±1.89
ENSMUST00000176701 N/A N/A 1.114±0.10 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000176895 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.451±0.88 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008QJ CIL_0008QJ_0002 VISTA 17:31053737-31653776
CIL_0000D3 CIL_0000D3_0002 CGP 17:31564749-31637199

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IMP angiogenesis
GO:0003677 IDA DNA binding
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0030097 IMP hemopoiesis
GO:0030217 IMP T cell differentiation
GO:0030218 IMP erythrocyte differentiation
GO:0043010 IMP camera-type eye development
GO:0043565 IDA sequence-specific DNA binding
GO:0045893 TAS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018765 pknox1.1 pbx/knotted 1 homeobox 1.1 protein_coding Danio_rerio
ENSDARG00000036542 pknox1.2 pbx/knotted 1 homeobox 1.2 protein_coding Danio_rerio
ENSDARG00000078080 pknox1.1 pbx/knotted 1 homeobox 1.1 protein_coding Danio_rerio
ENSG00000160199 PKNOX1 PBX/knotted 1 homeobox 1 protein_coding Homo_sapiens

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