C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear factor I/B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000008575 Nfib 10090 - 4:82290173-82705750 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000050872 Nfib-201 82290173-82505308 protein_coding
  ENSMUST00000064770 Nfib-202 82290176-82505308 protein_coding
  ENSMUST00000107245 Nfib-001 82290173-82505770 protein_coding
  ENSMUST00000107246 Nfib-007 82296081-82505770 protein_coding
  ENSMUST00000107247 Nfib-003 82296048-82505707 protein_coding
  ENSMUST00000107248 Nfib-002 82296048-82505707 protein_coding
  ENSMUST00000122918 Nfib-006 82326825-82505310 retained_intron
  ENSMUST00000135024 Nfib-008 82495984-82505779 retained_intron
  ENSMUST00000140874 Nfib-005 82328594-82505310 retained_intron
  ENSMUST00000148982 Nfib-011 82353052-82505764 retained_intron
  ENSMUST00000152588 Nfib-009 82498544-82499316 processed_transcript
  ENSMUST00000155821 Nfib-010 82498321-82705750 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000050872ENSMUST00000064770ENSMUST00000107245ENSMUST00000107246ENSMUST00000107247ENSMUST00000107248
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000050872 4.890±1.65 3.903±1.13 1.975±0.45 7.048±1.28 3.093±0.42 2.597±0.61 N/A 2.273±0.44 2.282±2.04 8.668±1.01 N/A 2.321±0.67 0.367±0.16 0.207±0.07
ENSMUST00000064770 10.002±0.90 7.984±0.52 11.134±0.93 14.473±7.32 8.227±1.08 2.632±0.51 14.837±1.78 4.922±0.77 2.497±1.34 17.975±1.07 6.318±1.68 4.755±1.35 0.948±0.52 0.347±0.08
ENSMUST00000107245 2.949±0.01 1.607±0.03 3.258±0.97 N/A 1.604±0.29 0.920±0.27 N/A 0.778±0.00 0.297±0.01 3.826±0.17 1.345±0.00 1.116±0.26 0.426±0.20 0.126±0.01
ENSMUST00000107246 N/A N/A N/A 10.268±0.00 N/A N/A N/A N/A N/A N/A N/A 10.689±0.00 1.163±0.56 0.913±0.00
ENSMUST00000107247 N/A 2.390±0.71 N/A N/A 3.519±0.76 1.423±0.41 N/A 2.195±0.42 2.177±0.23 N/A N/A 2.219±0.56 N/A 0.131±0.00
ENSMUST00000107248 4.863±0.00 1.634±0.12 N/A N/A 3.194±1.26 1.247±0.00 N/A N/A 3.614±0.00 N/A N/A 1.422±0.42 N/A 0.202±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000746 CIL_000746_0002 CGP 4:81278500-82705750
CIL_0007VJ CIL_0007VJ_0002 VISTA 4:81853582-82454380
CIL_000143 CIL_000143_0002 CGP 4:82290173-82859958

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 ISS sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IMP RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001106 IEA RNA polymerase II transcription corepressor activity
GO:0002062 IMP chondrocyte differentiation
GO:0003677 ISS DNA binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005634 IDA nucleus
GO:0005730 IEA nucleolus
GO:0006260 IEA DNA replication
GO:0006351 IEA transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008285 IMP negative regulation of cell proliferation
GO:0010001 IMP glial cell differentiation
GO:0021740 IMP principal sensory nucleus of trigeminal nerve development
GO:0021960 IMP anterior commissure morphogenesis
GO:0030324 IMP lung development
GO:0030900 IMP forebrain development
GO:0030902 IMP hindbrain development
GO:0043392 IEA negative regulation of DNA binding
GO:0044300 IDA cerebellar mossy fiber
GO:0045944 IDA:IMP positive regulation of transcription from RNA polymerase II promoter
GO:0060486 IMP Clara cell differentiation
GO:0060509 IMP Type I pneumocyte differentiation
GO:0060510 IMP Type II pneumocyte differentiation
GO:0061141 IMP lung ciliated cell differentiation
GO:0071679 IMP commissural neuron axon guidance
GO:2000791 IMP negative regulation of mesenchymal cell proliferation involved in lung development
GO:2000795 IMP negative regulation of epithelial cell proliferation involved in lung morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000147862 NFIB nuclear factor I/B protein_coding Homo_sapiens

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