C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rap guanine nucleotide exchange factor (GEF) 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022469 Rapgef3 10090 - 15:97744770-97767972 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000123397 Rapgef3-004 97746528-97767587 retained_intron
  ENSMUST00000125002 Rapgef3-016 97745368-97748872 retained_intron
  ENSMUST00000126854 Rapgef3-005 97744770-97767846 protein_coding
  ENSMUST00000128775 Rapgef3-003 97744956-97767664 protein_coding
  ENSMUST00000129223 Rapgef3-001 97744953-97767798 protein_coding
  ENSMUST00000134371 Rapgef3-013 97757454-97758842 nonsense_mediated_decay
  ENSMUST00000134885 Rapgef3-002 97745168-97767666 protein_coding
  ENSMUST00000135080 Rapgef3-006 97766859-97767972 protein_coding
  ENSMUST00000142196 Rapgef3-011 97760697-97761854 retained_intron
  ENSMUST00000146214 Rapgef3-014 97750357-97757502 retained_intron
  ENSMUST00000146620 Rapgef3-008 97760674-97767264 protein_coding
  ENSMUST00000149419 Rapgef3-009 97759359-97767046 nonsense_mediated_decay
  ENSMUST00000153241 Rapgef3-012 97758897-97760425 processed_transcript
  ENSMUST00000153464 Rapgef3-010 97759364-97761879 processed_transcript
  ENSMUST00000155810 Rapgef3-015 97749707-97750705 retained_intron
  ENSMUST00000175894 Rapgef3-018 97745285-97767420 nonsense_mediated_decay
  ENSMUST00000177352 Rapgef3-007 97745016-97767062 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000123397ENSMUST00000126854ENSMUST00000128775ENSMUST00000129223ENSMUST00000134885ENSMUST00000175894ENSMUST00000177352
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000123397 3.836±1.54 2.525±0.59 1.068±0.04 0.825±0.15 1.879±0.49 2.159±0.00 2.188±0.29 N/A 0.244±0.07 N/A 0.660±0.11 2.232±0.27 1.351±0.84 1.038±0.23
ENSMUST00000126854 1.640±0.00 4.037±1.93 0.964±0.00 N/A 1.839±0.00 2.482±0.03 N/A N/A 0.267±0.05 N/A 0.496±0.00 2.167±0.33 1.012±0.10 1.893±0.23
ENSMUST00000128775 N/A N/A N/A 2.089±0.00 0.790±0.00 2.394±0.08 N/A N/A 0.212±0.06 N/A 1.020±0.19 2.217±1.14 N/A N/A
ENSMUST00000129223 3.492±1.47 N/A 1.206±0.41 1.208±0.11 2.441±0.77 2.644±0.82 2.221±0.09 10.162±0.48 0.348±0.13 8.489±1.42 0.584±0.07 3.047±0.89 2.905±1.73 1.006±0.11
ENSMUST00000134885 N/A N/A N/A N/A N/A N/A N/A N/A 0.794±0.00 N/A 1.949±0.01 N/A N/A N/A
ENSMUST00000175894 3.155±0.00 4.989±1.91 N/A N/A 4.431±0.88 5.350±1.89 N/A N/A 0.333±0.07 8.435±0.00 N/A 2.486±0.00 5.677±5.23 N/A
ENSMUST00000177352 4.751±1.09 5.933±0.52 N/A N/A 4.759±1.80 8.771±1.93 3.925±0.49 11.908±1.53 0.674±0.16 12.133±3.43 1.443±0.31 8.621±1.95 2.383±0.14 1.420±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005YT CIL_0005YT_0002 CGP 15:97711019-97767972
CIL_0002OC CIL_0002OC_0002 CGP 15:97744770-97792692

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005737 IEA cytoplasm
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008603 IEA cAMP-dependent protein kinase regulator activity
GO:0016020 IEA membrane
GO:0017034 ISS Rap guanyl-nucleotide exchange factor activity
GO:0030552 IEA cAMP binding
GO:0032486 ISS Rap protein signal transduction
GO:0032854 ISS positive regulation of Rap GTPase activity
GO:0043547 IEA positive regulation of GTPase activity
GO:0045766 ISS positive regulation of angiogenesis
GO:0045859 IEA regulation of protein kinase activity
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0051496 ISS positive regulation of stress fiber assembly
GO:0061028 ISS establishment of endothelial barrier
GO:0070062 IEA extracellular vesicular exosome
GO:0071320 ISS cellular response to cAMP
GO:2000249 ISS regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079291 rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 protein_coding Danio_rerio
ENSG00000079337 RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 protein_coding Homo_sapiens

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